AI-Powered Longevity Science — One Gene to Reverse Aging? | Daniel Ives PhD

from Health Longevity Secrets · host Dr. Robert Lufkin MD

What if an AI could run centuries of aging experiments in a year? Dr. Daniel Ives, CEO of Shift Bioscience, explains how his team used a virtual cell to discover SB000 — a single gene that matches Yamanaka factor rejuvenation without cancer risk.CHAPTERS:00:00 — Centuries of experiments in a year02:03 — Daniel's journey: physics → Aubrey de Grey10:08 — The epigenetic clock breakthrough12:09 — The 13 mitochondrial genes20:09 — Yamanaka factors (OSKM) explained22:10 — Partial reprogramming: the weekend analogy24:11 — The cancer risk problem26:11 — AI virtual cell: how it works32:12 — AI-driven dark labs40:16 — Single-gene interventions42:17 — Shift's discovery: genes that reverse aging50:19 — Animal testing begins62:20 — Hearing loss: the unexpected aging connection66:21 — Rapamycin reverses hearing loss in animals78:25 — N=1 medicine and wearables84:26 — ClosingREFERENCES:Shift Bioscience: shiftbioscience.comPartial Reprogramming (Nature Comms, 2024): NatureEpigenetic Clock (Frontiers in Aging, 2024): FrontiersGUEST: Dr. Daniel Ives, PhD — CEO, Shift Bioscience, Cambridge UKHOST: Dr. Robert Lufkin MD | robertlufkinmd.com⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every other Tuesday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Episode metadata supplied by the publisher feed · Published Apr 28, 2026

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