Alan Green MD: Rapamycin for Longevity in Clinical Practice

#008-The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity.Take away points: -Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice.-In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice. -It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis.-The drug requires a prescription and should only be used under supervision of a physician-Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin]02:45 Blagosklonny papers (Blagosklonny 2019)05:23 Jane Mannick rapalogue paper (Mannick 2014)08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy09:14 Elevated mTOR as common factor- Inflammation, fibrosis, 12:03 Rapamycin role to decrease mTOR overview common pathway 14:23 mTOR is essentially command and control of the cell for the last 2 billion years15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects16:05 Increased mTOR causes increased innate immune system/inflammation 17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy 23:00 Alzheimer disease as a disease of senescent cells26:00 importance of dose timing for Rapamycin27:00 Anti aging effects on mTOR1 and other effects on mTOR232:00 Rapamycin as off patent drug37:00 Dosing considerations and subjective effects40:00 Tracking HOMA-IR  (Homeostatic Model Assessment for Insulin Resistance) score 42:00 Improvement in exercise related to maximum cardiac output45:00 Age associated cardiomyopathy49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections.57:00 Personal lifestyle choiceshttps://rapamycintherapy.com/ Rapamycin Clinical Registryhttps://www.rapamycin.io/Blagosklonny, Mikhail V. “Rapamycin for Longevity: Opinion Article.” Aging 11, no. 19 (October 4, 2019): 8048–67. https://doi.org/10.18632/aging.102355.Harrison, David E., Randy Strong, Zelton Dave Sharp, James F. Nelson, Clinton M. Astle, Kevin Flurkey, Nancy L. Nadon, et al. “Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice.” Nature 460, no. 7253 (July 2009): 392–95. https://doi.org/10.1038/nature08221.Mannick, J. B., G. Del Giudice, M. Lattanzi, N. M. Valiante, J. Praestgaard, B. Huang, M. A. Lonetto, et al. “MTOR Inhibition Improves Immune Function in the Elderly.” Science Translational Medicine 6, no. 268 (December 24, 2014): 268ra179-268ra179. https://doi.org/10.1126/scitranslmed.3009892.*** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmd*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contactDisclaimer: We are ambassadors or affiliates for many of the brands we reference on the channel. ------------------------------------------------------------------------#longevity  #wellness #antiaging #biologicalage #lifestylemedicine #younger #epigenetics #biohacking  #Rapamycin #RobertLufkinMD⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every other Tuesday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/