Amiodarone

•Trade – Cordarone •Class – Antiarrhythmic •MOA - Acts directly on the myocardium to delay repolarization and increase the duration of action potential •Indications – Ventricular arrhythmias, second line for atrial rhythms. •Contraindications – Sick sinus syndrome, second and third degree heart block, cardiogenic shock, when episodes of bradycardia have cause syncope, sensitivity to benzyl alcohol and iodine. •Side effects – Burning at the IV site, hypotension, bradycardia. •Dosing Ventricular Fibrillation, and Pulseless Ventricular Tachycardia Adult: 300mg IV/IO followed by 150mg in 3-5 mins 1mg/min maintenance infusion after ROSC Pedi: 5mg/kg max dose 300mg may repeat 5mg/kg up to 15mg/kg Stable Wide Complex Tachycardia Adult: 150mg over 10 mins. Pedi: 5mg/kg IV/IO over 20-60 mins