Ask Me Anything About Nutrition, March 8, 2019 | Mastering Nutrition #65

On March 8, members of the CMJ Masterpass joined me in a live Zoom meeting to ask me anything about nutrition, and here's the full recording! We talk about things like: What to do if zinc causes nausea?  When on a ketogenic diet, it is a problem if ketones are going up to 5 to 6 millimoles per liter? What if I'm on a ketogenic diet, and I can't get my ketone levels up higher than 1 millimole per liter when my primary reason for being on the ketogenic diet is that I'm trying to control blood glucose better? Advice for what to do after suffering a transient ischemic attack. Nutrients important for neuroregeneration. What causes sinus congestion, and what can help? Nutrition for children with ADHD. Nutritional recommendations for MTR and MTRR polymorphisms. Why the main problem with hyperglycemia is not glucose but rather advanced glycation end products, and why the main determinant of advanced glycation end products is low insulin signaling. Does the difference between cyanocobalamin, hydroxocobalamin, and methylcobalamin matter, and does the difference between sublingual, oral, and intramuscular injection matter? Could fat malabsorption be driven by genetic polymorphisms that lower activity the PEMT enzyme? And could fat malabsorption in general be causing not only mineral deficiencies but also hyperabsorption of oxalate from foods? Why am I always sneezing first thing in the morning? What if I cannot get my ferritin up and supplementing iron actually raises my serum iron well above the normal range? A rant on why many people use "MTHFR" to slap a label on their health problems. All this and much more! If you'd like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition  This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral  This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order." This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral  In this episode, you will find all of the following and more: 00:43 Cliff Notes 11:13 Introduction 13:23 Should blacks and whites have different normal ranges for their HDL cholesterol? And general principles we should keep in mind when thinking about interracial differences or differences between groups. 17:24 Are there any solutions to getting nauseated from zinc supplements even at low doses and even when the zinc comes as oysters? 22:35 When on a ketogenic diet, it is a problem if ketones are going up to 5 to 6 millimoles per liter? 26:17 Advice for what to do after suffering a transient ischemic attack 35:57 Nutrients important for neuroregeneration 39:26 What causes sinus congestion, and what can help? 42:36 Do MTHFR polymorphisms other than the famous C677T and A1298C matter at all? 44:54 Nutrition for children with ADHD 57:07 How to address orthostatic hypotension 58:53 Nutritional recommendations for MTR and MTRR polymorphisms 01:10:54 Do you know anything about the value of lithium for ADHD? 01:11:08 Information about my free Vitamins and Minerals 101 class 01:13:30 Why the main problem with hyperglycemia is not glucose but rather advanced glycation end products, and why the main determinant of advanced glycation end products is low insulin signaling. 01:24:19 Thoughts on nutrition and breast health 01:33:03 Is it useful to measure urine pH? 01:39:57 What would be a high dose of iodine? 01:41:29 Recommended dose of glycine 01:43:31 Does the difference between cyanocobalamin, hydroxocobalamin, and methylcobalamin matter, and does the difference between sublingual, oral, and intramuscular injection matter? 01:53:10 Are bilirubin and uric acid useful markers of antioxidant defense and oxidative stress? What are better markers? 01:58:25 Could an elevated BUN indicate protein malabsorption and low stomach acid? 02:03:31 What if I'm on a ketogenic diet, and I can't get my ketone levels up higher than 1 millimole per liter when my primary reason for being on the ketogenic diet is that I'm trying to control blood glucose better? 02:04:39 Could fat malabsorption be driven by genetic polymorphisms that lower activity the PEMT enzyme? And could fat malabsorption in general be causing not only mineral deficiencies but also hyperabsorption of oxalate from foods? 02:08:18 How to manage blood levels of omega-3 and omega-6 fatty acids 02:09:57 Why am I always sneezing first thing in the morning? 02:12:03 Follow-up to question about ketone levels 02:12:48 What if I cannot get my ferritin up and supplementing iron actually raises my serum iron well above the normal range? 02:19:25 What about pyroluria and measuring kryptopyrroles? 02:22:51 Are there safety concerns in supplementing cyanocobalamin rather methylcobalamin in those with MTHFR polymorphisms? And a rant on why many people use "MTHFR" to slap a label on their health problems. 02:34:14 Advice for patient with hypercholesterolemia, elevated fasting glucose and insulin, ferritin of 194, and iron saturation of 33% 02:45:31 What to do about high fasting glucose that only seems to improve with long sleep 02:48:00 What should the upper limit of fatty fish intake be? Access the show notes, transcript, and comments here: https://chrismasterjohnphd.substack.com/p/065-ask-me-anything-about-nutrition Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.