PODCAST · health
Mastering Nutrition
by Chris Masterjohn, PhD
Welcome to the Mastering Nutrition podcast.Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks.He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.
Episodes
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Depression Starts In Your Mitochondria
You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease. Find it at mito.me This is not medical advice and is for...
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Aging is best explained by declining mitochondrial function over time.
Aging is best explained by declining mitochondrial function over time. This answers its own "why." Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost. But how much is under your control. From Joe Rogan Experience JRE...
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The Medical Myth That Nutritional Deficiencies Are A Thing of the Past
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0 Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
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Why Doctors Think They Can Ignore the Studies Suggesting Seed Oils Cause Heart Disease
This is a clip from Joe Rogan Experience JRE 2420. Watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
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The Problem With Seed Oils and Why They Are So Controversial
This is a clip from Joe Rogan Experience Episode 2420. You can watch the full interview here: https://www.youtube.com/watch?v=QBn54YNnKD0
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Mitochondria: Why They Control Everything in Human Health
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair, distribute, and organize everything in your body. Abundant health right now,...
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SSRI Withdrawal Is Mitochondrial Dysfunction
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americans and about 5-10% of the world's population are on SSRIs, which have become...
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How Lactate Alkalinizes Your Muscles
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some people still believe this. You may have heard the argument against it from...
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D-Lactate: Groundbreaking Research No One Is Talking About
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bacteria, D-lactate is also inarguably and irrefutably produced by human…
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Handling Creatine Side Effects
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of asthma, bloody noses, anxiety, headaches, heart palpitations, twitching, and...
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Your Cells Are Starving For Creatine
Creatine is like your second mitochondria. Or, the mitochondria's chief of staff. Or its co-pilot. Your mitochondria make ATP so you can see clearly, hear accurately, digest your food, power your brain, show off your your shiny skin, lift heavy things, and perform your best at the challenges you...
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Is Whole Food Vitamin C Really Different? | Masterjohn Q&A Files #330
Question: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex? Short Answer: Vitamin C is nearly ubiquitously distributed in plant tissues, and is never bound to any enzyme as a structural complex. Vitamin C promotes absorption of iron from plant foods, inhibits...
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What's the Deal With Seed Oils? | Masterjohn Q&A Files #329
Question: What Is the Real Issue With Seed Oils? Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not acutely cause oxidative stress, but their polyunsaturated fatty acids (PUFAs) are more vulnerable than any other macronutrient to oxidative damage....
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Is Hair Mineral Testing Useful? | Masterjohn Q&A Files #328
Question: How useful is hair trace mineral analysis (HTMA) for nutritional testing? Short Answer: Hair trace mineral analysis is included as an optional add-on in the comprehensive nutritional screening from Testing Nutritional Status: The Ultimate Cheat Sheet, because it can capture data for…
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Secrets to Superior Cognitive Performance (Without Drugs)
Nutrition is far more powerful than drugs to improve cognitive performance. We start by looking at cocaine, Adderall, and Ritalin, and show why these drugs cannot possibly hold a candle to nutrition. Optimal nutrition can definitely optimize the function of dopamine, norepinephrine…
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Vitamin C, Whole Food Vs. Synthetic: Does It Matter?
Debunking the myth that vitamin C in plants is found in a special "tyrosinase complex." For the written article with references, see here: https://chrismasterjohnphd.substack.com/p/vitamin-c-whole-food-vs-synthetic For issues of vitamin C dosing and balancing with other nutrients, see these two...
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Fact-Checking Gary Brecka on Rogan: A Deep Dive into MTHFR and Methylation
Watch or listen to the full critique here: https://www.youtube.com/watch?v=kMPvCiOkEtQ Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
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Cancer, IV Drips, and the Glutathione Vitamin C Connection
Is high-dose vitamin C good for you? High-dose intravenous vitamin C can selectively kill cancer cells in live patients and can save sepsis patients from dying, but it acts as a pro-oxidant in cancer and an antioxidant in sepsis. So what does it do in the rest of us? Oral doses of 2000 milligrams...
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How to Find the Root Cause of Autoimmunity? | Masterjohn Q&A Files #327
Question: How to Find the Root Cause of Autoimmunity? Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to...
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The Powerful Duo: How Glutathione and Vitamin C IV Drips Impact Cancer
High-dose intravenous (IV) vitamin C has the potential to kill cancer cells and prolong the survival of terminal cancer patients. This podcast is a preview, the full video is available only to Masterpass members. See the written article with links to references here:...
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Startled?! Try Glycine!
The ability to become startled is an adaptive behavior that protects us from being injured by a sudden threat, and prepares us for the fight-or-flight response when necessary. Nevertheless, getting startled too easily can be a sign that something is wrong. Here's what to do about it. For the...
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Hormones Are Never In Charge
Hormones matter, but they are never in charge. Their abnormalities are never the root cause of anything. All hormones do is communicate the biochemistry of one tissue to the biochemistry of another tissue. In this episode: Three Reasons For Hormones to Be Messed Up Exceptions to the Rule Leptin,...
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Biotin's Health Benefits: Way Beyond Hair and Nails
Most people who take biotin take it for their hair and nails. Yet biotin does much more than this. Learn what to use it for, how much to take, and how to avoid adverse effects in less than ten minutes. Read the written and fully referenced version here:...
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Exposing Harmful Supplements: Biotin's Dark Side
This is how to use a simple home measurement to expose the harmful effects of a supplement before they even happen. Read the article here: https://chrismasterjohnphd.substack.com/p/the-dark-side-of-biotin Subscribe to my newsletter to get my series on improving respiratory chain function as soon…
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Why Would Vitamin C cause muscle pain, joint pain, and brain fog? | Masterjohn Q&A Files #326
Question: Why Would Vitamin C cause muscle pain, joint pain, and brain fog? Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This...
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Why You Need THIS Supplement On a High-Protein Diet: Game-Changing Effects Explained by a PhD
If you are eating a high-protein diet, you probably aren't getting enough biotin. This is especially true if you are a protein-fueled athlete and find your skin too oily, too itchy, or too red; if your blood sugar is getting out of control; or if you simply feel down in the dumps. And it's...
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Why High-Dose Biotin Could be the Answer for Your Blood Sugar, Brains, and Beauty
The use of high-dose biotin supplements has increased almost 30-fold over the last twenty years for such problems as diabetes, smell and taste disorders, disorders of the hair, skin, and nails, and multiple sclerosis. Studies show it can improve diabetes, and case reports show it can miraculously...
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A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn't, Analyze
The most useful tests are the ones no one ever orders. This podcast is available for free for 48 hours, and then will only be available to Masterpass members. The written and fully referenced article, the podcast, and the permanently available video can be found here:...
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Can NAC hurt your gut health? | Masterjohn Q&A Files #325
Question: Can NAC hurt your gut health? Short Answer: N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days to disrupt biofilms and make it easier for antimicrobials to kill bacteria. Animal studies suggest that acute doses up to 6 grams do not deplete…
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How I Found My Health "Super Unlock" After 20 Years of Research and 20,000 Genes Tested
Each person has one to six highly unique unlocks that will only work for them, and this is how to find them. This podcast is only available here for the next 48 hours. This video is a free preview of a full-length 69-minute podcast. You can access the full video, full podcast, and the written and...
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How can I protect against oxalates? | Masterjohn Q&A Files #324
Question: How can I protect against oxalates? Short Answer: Getting 300-400 mg calcium between food and supplements at each meal will minimize oxalate absorption. Maintaining postprandial urine pH in the 6.4-6.8 range by getting 3-5 grams of potassium per day from food or from organic acid salts...
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Why Should Postprandial Glucose Be Kept Under 140 mg/dL? | Masterjohn Q&A Files #323
Question: Why should postprandial blood glucose be kept under 140 milligrams per deciliter? Short Answer: When blood glucose rises above 140 mg/dL, this is the approximate point at which it spills into the polyol pathway at a greater-than-normal rate, which represents a suboptimal state of...
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Methylene Blue in 10 Minutes
Watch the full-length video here: https://www.youtube.com/watch?v=XhgGGbdw4zE&t=8621s Get my free 51--page report, Methylene Blue: Biohacker's Delight or Playing With Fire?, here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue Chris Masterjohn, PhD, is the Founder and...
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Methylene Blue: Biohacker's Delight, or Playing With Fire?
Get the written and referenced version here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue This is a 51-page guide in which you will learn the following: The Origin of Methylene Blue The Entry of Methylene Blue Into Medicine From Malaria to Many Uses in Medicine How...
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What is the relationship between copper and estrogen? | Masterjohn Q&A Files #322
Question: What is the relationship between copper and estrogen? Short Answer: Estrogen moves copper from the mother's bloodstream to the fetus during pregnancy. Its action at the intestines is poorly understood but I believe estrogen and progesterone interact to promote intestinal copper...
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Why Would Citrate or Malate Cause Insomnia?
This is now subscribers-only and is available here: https://chrismasterjohnphd.substack.com/p/why-would-citrate-or-malate-cause Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
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What to Do About Constipation
This is now subscribers-only and can be accessed here: https://chrismasterjohnphd.substack.com/p/what-to-do-about-constipation Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
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How to slow or reverse graying of hair? | Masterjohn Q&A Files #321
Question: How to slow graying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of energy abundance (body fat, insulin sensitivity, thyroid hormone, adequate...
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How Much Iron Can We Absorb At Once? | Masterjohn Q&A Files #320
Question: How much iron can we absorb at once? Short Answer: High-dose iron will produce more total absorbed iron, but will also leave more in the gut, which could cause constipation or disturb the gut microbiome. If desperate for quick relief, 200 milligrams per day of iron taken in the morning...
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What cofactors are needed to synthesize and recycle BH4? | Masterjohn Q&A Files #319
Question: What cofactors are needed to synthesize and recycle BH4? Short Answer: Zinc, magnesium, potassium, and niacin are the cofactors needed for the synthesis and recycling of BH4. Folate and methylation are not involved, though high-dose folate or folic acid could hypothetically hurt BH4...
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Is It Important to Get Vitamin D Sulfate Specifically From the Sun? | Masterjohn Q&A Files #318
Question: Is it important to get vitamin D sulfate specifically from the sun? Short Answer: It is important to get morning outdoor sunlight as close to every day as possible for your circadian rhythm, and to get some exposure to unprotected sunlight during the day when UV is available, but at…
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When to Consider Inborn Errors of Metabolism
These are considered rare, yet this reinforces the pattern of never looking for them, leading them to likely be massively under-diagnosed. Many are highly relevant to nutrition. Written Version: https://chrismasterjohnphd.substack.com/p/when-to-consider-inborn-errors-of Mitochondrial Energy…
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How to Recover From Fish Oil
Iris from Denmark has generously donated an hour of her consulting time with me to you, the community, so that her case can be used to raise awareness of the importance of arachidonic acid and the pitfalls of getting too much EPA. In this podcast, we cover: 00:27 Iris's history of too much…
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Can B12 and Folate Help Detoxify Oxalate?
This may explain why high-dose biotin causes "oxalate dumping" symptoms in some people but not others. Written and referenced version: https://chrismasterjohnphd.substack.com/p/can-b12-and-folate-help-detoxify Mitochondrial Energy Summit:...
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If I have a hereditary weakness in breaking down branched-chain amino acids, what cofactors do I need to consider, and do I need to restrict my protein when losing weight? | Masterjohn Q&A Files #317
Question: If a person has a hereditary weakness for Branched Chain Amino Acid Catabolism would this impact the type of diet they might choose to loose weight? Should they limit protein if it will increase their need for nutrients like Biotin?What are all the possible cofactors we should consider...
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How do I consume omega-3 without hurting my omega-6 status? | Masterjohn Q&A Files #316
Question: If I don't want to hurt my omega 6 status through my omega 3 intake, how do I do that? Is it simply a question of taking them at separate times? Or is it a question of dose? And if it is a question of dose, how do I know when to start eating fish and taking my omega 3 supplement again?...
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Energy Metabolism Governs Everything
That was not an exaggeration. Everything. In this podcast I cover why riboflavin abolished my allergies, why a respiratory chain disorder could cause an autoimmune condition, and why a hypothetical athlete who went keto to take home the silver might be able to use thiamin to take home the gold....
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Can plant foods and their phytochemicals be used to reduce arterial plaque? | Masterjohn Q&A Files #315
Question: Can plant foods and their phytochemicals be used to reduce arterial plaque? Short Answer: Yes, but if you don't have specific intolerances to plant compounds the best thing to do is simply aim to meet your vitamin and mineral targets from a diet rich in fruits, vegetables, herbs, and...
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What to Do About Twitching | Masterjohn Q&A Files #314
Question: What can be done about twitching? Short Answer: Most twitching will be driven by glutamate/GABA balance or acetylcholine regulation, and the most likely nutritional issues are any of the electrolytes or any factor that influences energy metabolism. The best way to address it is to...
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Can Biotin Help Detoxify Oxalate?
This is a hypothesis that may reconcile some anecdotes and has many hints suggested in the enzymological literature. First, make sure you get my MTHFR Protocol, my free 7-page quick guide to optimizing and personalizing your methylation status, here:...
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ABOUT THIS SHOW
Welcome to the Mastering Nutrition podcast.Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks.He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign's College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.
HOSTED BY
Chris Masterjohn, PhD
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Frequently Asked Questions
How many episodes does Mastering Nutrition have?
Mastering Nutrition currently has 712 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Mastering Nutrition about?
Welcome to the Mastering Nutrition podcast.Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research...
How often does Mastering Nutrition release new episodes?
Mastering Nutrition releases new episodes frequently with a large back catalog of 712 episodes. Check the episode list for recent publication dates.
Where can I listen to Mastering Nutrition?
You can listen to Mastering Nutrition on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts Mastering Nutrition?
Mastering Nutrition is created and hosted by Chris Masterjohn, PhD.
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