ATTR Amyloidosis: Missed HF Diagnosis in Minorities 09/13/25

Welcome to Cardiology Today – Recorded September 13, 2025. This episode summarizes 5 key cardiology studies on topics like acute myocardial infarction and digital health. Key takeaway: ATTR Amyloidosis: Missed HF Diagnosis in Minorities. Article Links: Article 1: Approach to the Postmarket Evaluation of Consumer Wearable Technologies. (JAMA cardiology) Article 2: Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies. (JAMA cardiology) Article 3: Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. (JAMA cardiology) Article 4: Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial. (Heart (British Cardiac Society)) Article 5: Long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/attr-amyloidosis-missed-hf-diagnosis-in-minorities-09-13-25/ Featured Articles Article 1: Approach to the Postmarket Evaluation of Consumer Wearable Technologies. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928810 Summary: This article discusses the need for empirical research on the postmarket use of consumer wearable technologies. The Stanford Center for Digital Health organized think tank meetings to develop a framework for evaluating these devices after they have been released to the public. The focus is on gathering data regarding real-world performance, accuracy, and potential impact on patient outcomes. Article 2: Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928770 Summary: This study addresses the challenge of assessing the hemodynamic significance of right anomalous aortic origin of a coronary artery. Invasive fractional flow reserve during a dobutamine-atropine volume challenge is the reference standard, but noninvasive imaging modalities are being explored as a less invasive alternative. The research aims to determine if noninvasive imaging can accurately evaluate dynamic compression of the anomalous vessel. Article 3: Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40928765 Summary: This study investigates the prevalence of transthyretin cardiac amyloidosis in older Black and Hispanic individuals with heart failure. The research aims to determine the proportion of heart failure cases in these populations attributable to both wild-type and variant transthyretin cardiac amyloidosis, including the V142I variant common in Black Americans. Understanding this prevalence is crucial for improving diagnosis and treatment in at-risk groups. Article 4: Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40908114 Summary: This analysis of the Colchicine and Spironolactone in Patients with Left Ventricular Dysfunction after Myocardial Infarction (CLEAR) trial uses generalized pairwise comparisons to assess the benefit-risk profiles of colchicine and spironolactone in acute myocardial infarction. This method allows for a hierarchical ranking of clinical outcomes, providing a more intuitive understanding of treatment trade-offs compared to composite endpoints. The analysis explores the overall clinical benefit considering different event severities. Article 5: Long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40368452 Summary: This post hoc analysis of the Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment Extended Follow-up study compares long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. It seeks to evaluate if intravascular ultrasound-guided percutaneous coronary intervention is comparable to coronary artery bypass grafting in improving long-term clinical outcomes in patients with multivessel disease. The focus is on patients who were treated with either procedure as part of the original clinical trial. Transcript Today’s date is September 13, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Approach to the Postmarket Evaluation of Consumer Wearable Technologies. This article discusses the need for empirical research on the postmarket use of consumer wearable technologies. The Stanford Center for Digital Health organized think tank meetings to develop a framework for evaluating these devices after they have been released to the public. The focus is on gathering data regarding real-world performance, accuracy, and potential impact on patient outcomes. Article number two. Noninvasive Anatomical and Functional Imaging for Hemodynamic Relevance in Right Coronary Artery Anomalies. This study addresses the challenge of assessing the hemodynamic significance of right anomalous aortic origin of a coronary artery. Invasive fractional flow reserve during a dobutamine-atropine volume challenge is the reference standard, but noninvasive imaging modalities are being explored as a less invasive alternative. The research aims to determine if noninvasive imaging can accurately evaluate dynamic compression of the anomalous vessel. Article number three. Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Individuals With Heart Failure. This study investigates the prevalence of transthyretin cardiac amyloidosis in older Black and Hispanic individuals with heart failure. The research aims to determine the proportion of heart failure cases in these populations attributable to both wild-type and variant transthyretin cardiac amyloidosis, including the V142I variant common in Black Americans. Understanding this prevalence is crucial for improving diagnosis and treatment in at-risk groups. Article number four. Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial. This analysis of the Colchicine and Spironolactone in Patients with Left Ventricular Dysfunction after Myocardial Infarction (CLEAR) trial uses generalized pairwise comparisons to assess the benefit-risk profiles of colchicine and spironolactone in acute myocardial infarction. This method allows for a hierarchical ranking of clinical outcomes, providing a more intuitive understanding of treatment trade-offs compared to composite endpoints. The analysis explores the overall clinical benefit considering different event severities. Article number five. Long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. This post hoc analysis of the Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment Extended Follow-up study compares long-term outcomes of intravascular ultrasound-guided percutaneous coronary intervention versus coronary artery bypass grafting for multivessel coronary artery disease. It seeks to evaluate if intravascular ultrasound-guided percutaneous coronary intervention is comparable to coronary artery bypass grafting in improving long-term clinical outcomes in patients with multivessel disease. The focus is on patients who were treated with either procedure as part of the original clinical trial. Thank you for listening. Don’t forget to subscribe. Keywords acute myocardial infarction, digital health, multivessel coronary artery disease, percutaneous coronary intervention, colchicine, heart failure, postmarket evaluation, coronary artery bypass grafting, spironolactone, hemodynamic significance, noninvasive imaging, fractional flow reserve, coronary artery anomaly, transthyretin cardiac amyloidosis, consumer wearables, intravascular ultrasound, Hispanic Americans, US Food and Drug Administration, Black Americans, generalized pairwise comparisons. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post ATTR Amyloidosis: Missed HF Diagnosis in Minorities 09/13/25 first appeared on Cardiology Today.