BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems

See references below for related reading.10.1      Introduction and overview10.1.1    Some of the advantages of therapeutic genes10.1.2    Some of the advantages of molecular biosensor feedback control systems10.1.3    Why a nanodelivery approach is appropriate10.2      The therapeutic gene approach10.2.1    What constitutes a "therapeutic gene" ?10.2.2    Transient versus stable expression modes10.3      Molecular feedback control systems10.3.1    Drug delivery has traditionally not used feedback controls10.3.2    Why feedback control might be a very good idea!10.3.3    Positive or negative feedback?10.4      Molecular Biosensors as a component of a nanomedicine feedback control system10.4.1    What is a molecular biosensor?10.4.2    How a molecular biosensor functions as a therapeutic gene switch10.5      Building integrated molecular biosensor/gene delivery systems –some examples10.5.1    Example of a ribozyme/antivirus system10.5.2    Example of an ARE biosensor/DNA repair system10.5.3    Example of a feedback-controlled system for treatment of retinopathies