[Audio] BME 695L: Engineering Nanomedical Systems

Episodes

1. 19

   BME 695L Special Lecture 4: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)

   Guest lecturer: Helen McNally

   Dec 2, 2011
2. 18

   BME 695L Special Lecture 3: In vivo Model Systems to Study Nanomedical Approaches to Cancer Detection and Intervention

   Guest lecturer: Deborah Knapp.

   Dec 2, 2011
3. 17

   BME 695L Lecture 15: GMP and Issues of Quality Control Manufacture of Nanodelivery Systems

   See references below for related reading.15.1 Overview15.1.1 What does cGMP mean?15.1.2 Why GMP? Controlling processes means more predictable outcomes…15.1.3 Enforcement15.1.4 What can be learned from the semi-conductor industry clean-room and manufacturing?15.1.5 What doesn’t fit this...

   Dec 2, 2011
4. 16

   BME 695L Lecture 16: FDA and EPA Regulatory Issues

   See references below for related reading.16.1 Introduction and overview16.1.1 How does the FDA think about nanomedical systems?16.1.2 The 2006 Nanotechnology Task Force16.2 Some details of the Nanotechnology Task Force Report16.2.1 General findings of the report16.2.2 Some initial recommendations...

   Dec 2, 2011
5. 15

   BME 695L Lecture 12: Assessing Drug Efficacy and Nanotoxicity at the Single Cell Level

   See references below for related reading.12.1 Introduction to measures of efficacy for nanomedicine12.1.1 for evaluation purposes, does structure/size reveal function?12.1.2 nanomedical treatment at the single cell level requires evaluation at the single cell level12.1.3 the difficulty of…

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   Nov 23, 2011
6. 14

   BME 695L Lecture 13: Designing Nanomedical Systems (NMS) for In-vivo Use

   See references below for related reading.13.1 Bringing in-vivo considerations into NMS design13.1.1 the in-vitro to ex-vivo to in-vivo paradigm 13.1.1.1 In-vitro - importance of choosing suitable cell lines 13.1.1.2 adding the complexity of in-vivo background while keeping the simplicity of...

   Nov 23, 2011
7. 13

   BME 695L Lecture 14: Designing and Testing Integrated Nanomedical Systems

   See references below for related reading.14.1 Introduction to integrated designs14.1.1 “Total design” but there is some order in the design process14.1.2 A brief outline of the total design process14.2 Choose autonomous or non-autonomous design14.2.1 If autonomous, will there be error-checking to...

   Nov 23, 2011
8. 12

   BME 695L Special Lecture 2: X-ray Photoelectron Spectroscopy (XPS) in Biologically-Relevant Applications

   Guest lecturer: Dmitry Zemlyanov

   Nov 1, 2011
9. 11

   BME 695L Lecture 11: Assessing Nanotoxicity at the Single Cell Level

   See references below for related reading.11.1 Need for single cell measures of nanotoxicity11.1.1 There is more than one way for a cell to die...11.1.2 "Necrosis" vs. "Apoptosis"11.1.3 There are other forms of "toxicity"11.1.4 Some other challenges in measuring toxicity of nanomaterials11.2...

   Oct 27, 2011
10. 10

    BME 695L Lecture 10: Nanodelivery of Therapeutic Genes and Molecular Biosensor Feedback Control Systems

    See references below for related reading.10.1 Introduction and overview10.1.1 Some of the advantages of therapeutic genes10.1.2 Some of the advantages of molecular biosensor feedback control systems10.1.3 Why a nanodelivery approach is appropriate10.2 The therapeutic gene approach10.2.1 What...

    Oct 26, 2011
11. 9

    BME 695L Lecture 9: Challenges of Proper Drug Dosing with Nanodelivery Systems

    See references below for related reading.9.1 Overview of drug dosing problem9.1.1 Problems of scaling up doses from animal systems9.1.2 Basing dosing on size, area, weight of recipient9.1.3 Vast differences between adults in terms of genetics, metabolism9.1.4 Dosing in children – children are NOT...

    Oct 19, 2011
12. 8

    BME 695L Lecture 8: Surface Chemistry: attaching nanomedical structures to the core

    See references below for related reading.8.1 Introduction8.1.1 attachment strategies typically depend on core composition8.1.2 but the attachment strategy should not drive the core choice8.1.3 the choice of core should still depend on the desired overall “multifunctional” nanomedical device8.2...

    Oct 12, 2011
13. 7

    BME 695L Lecture 6: Normal & Facilitated Cell Entry Mechanisms

    See references below for related reading.6.1 Introduction6.1.1 the general problem of cell entry6.1.2 choosing modes of cell entry6.1.3 how does Nature do it? (biomimetics)6.2 Non-specific uptake mechanisms6.2.1 pinocytosis by all cells6.2.2 phagocytosis by some cells6.2.3 a recent study of Qdot…

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    Oct 4, 2011
14. 6

    BME 695L Lecture 7: Assessing Zeta Potentials

    See references below for related reading.7.1 Introduction – the importance of the zeta potential7.1.1 nanoparticle-nanoparticle interactions7.1.2 nanoparticle-cell interactions7.1.3 part of the initial nanomedical system-cell targeting process7.1.4 low zeta potential leads to low serum protein...

    Oct 3, 2011
15. 5

    BME 695L Lecture 5: Nanomaterials for Core Design

    See references below for related reading.5.1 Introduction5.1.1 core building blocks5.1.2 functional cores5.1.3 functionalizing the core surface5.2 Ferric oxide cores5.2.1 paramagnetic cores5.2.2 superparamagnetic cores5.2.3 ferric nanorods5.2.4 advantages and disadvantages5.3 C60 and carbon...

    Oct 3, 2011
16. 4

    BME 695L Lecture 4: Cell Targeting and its Evaluation

    See references below for related reading.4.1 Overview: targeting nanosystems to cells4.1.1 antibody targeting4.1.2 peptide targeting4.1.3 aptamer targeting4.1.4 ligand-receptor targeting4.2 Antibodies – polyclonal and monoclonal4.2.1 Where do antibodies come from – in nature?4.2.2 How do we make...

    Oct 3, 2011
17. 3

    BME 695L Lecture 3: Theranostics and Molecular Imaging

    See references below for related reading.3.1 Nanomedical systems – levels of challenges3.1.1 Diagnosis - difficult3.1.2 Therapy – more difficult3.1.3 Both ("Theragnosis") – most difficult!3.2 How theragnostics relates to Molecular Imaging3.2.1 conventional imaging is not very specific3.2.2 types…

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    Sep 7, 2011
18. 2

    BME 695L Lecture 1: Need for New Perspectives on Medicine

    See references below for related reading.1.1 Nanotechnology – Why is something so small so big?1.1.1 Definitions of nanotechnology based on size1.1.2 A “bottoms up” rather than “tops down” approach1.1.3 The nanoworld challenges our perspectives on size1.2 The Progression of Medicine1.2.1...

    Aug 31, 2011
19. 1

    BME 695L Lecture 2: Designing Nanomedical Systems

    See references below for related reading.2.1 Elements of good engineering design2.1.1 Whenever possible, use a general design that has already been tested2.1.2 Whenever possible, take advantage of “biomimicry” – Nature has tried many designs!2.1.3 Avoid “general purpose” design. Use multiple...

    Aug 31, 2011