BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression modesMolecular feedback control systemsDrug delivery has traditionally not used feedback controlsWhy feedback control might be a very good idea!Positive or negative feedback?Molecular Biosensors as a component of a nanomedicine feedback control systemWhat is a molecular biosensor?How a molecular biosensor functions as a therapeutic gene switchBuilding integrated molecular biosensor/gene delivery systems –some examplesRequired componentsExample of a ribozyme/antivirus systemExample of an ARE biosensor/DNA repair system