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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)

by James Leary

This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...

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Episodes

  1. BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention

    With Deborah Knapp as guest lecturer.

  2. BME 695N Lecture 21: FDA and EPA Regulatory Issues

    Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the report Some initial recommendations of the Task Force Where the FDA may need to meet EPA on nanoscale...

  3. BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems

    Outline:Overview What does cGMP mean? Why GMP? Controlling processes means more predictable outcomes… Enforcement What can be learned from the semi-conductor industry clean-room and manufacturing? What doesn’t fit this paradigm?cGMP-level manufacturing Predictable methods lead to predictable...

  4. BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use

    Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplicity of in-vitro In-vivo - all the complexity of ex-vivo plus the “active” components of a real...

  5. BME 695N Lecture 17: Assessing nanotoxicity at the single cell level

    Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challenges in measuring toxicity of nanomaterialsNecrosis vs. Apoptosis mechanisms Necrosis is unplanned…

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  6. BME 695N Lecture 16: Assessing drug efficacy at the single cell level

    Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of anything but simple functional assaysThe need for assays which at least show correlation to...

  7. BME 695N Lecture 15: Nanodelivery of therapeutic genes & molecular biosensor feedback control systems

    Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe therapeutic gene approachWhat constitutes a "therapeutic gene" ?Transient versus stable expression...

  8. BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems

    Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metabolismDosing in children – children are NOT smaller adults!Pharmacokinetics – drug distribution,...

  9. BME 695N Lecture 13: Assessing Zeta Potentials

    Outline:Introduction – the importance of the zeta potentialNanoparticle-nanoparticle interactionsNanoparticle-cell interactionsPart of the initial nanomedical system-cell targeting processLow zeta potential leads to low serum protein binding and potentially longer circulationZeta potential...

  10. BME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications

    With Dmitry Zemlyanov as guest lecturer.

  11. BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles

    With Donald E. Bergstrom as guest lecturer.

  12. BME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles)

    What Helen McNally as guest lecturer.

  13. BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo

    Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by confocal microscopySingle-cell image/confocal analysisFlow cytometric quantitation of NMS binding to...

  14. BME 695N Lecture 10: Nanomaterials for core design

    Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and carbon nanotubesSize and structure of C60Elongation of C60 into carbon nanotubesAdvantages and...

  15. BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells

    Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have X-ray...

  16. BME 695N Lecture 7: Normal & facilitated cell entry mechanisms

    Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin…

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  17. BME 695N Lecture 5: Cell Targeting

    Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make them in the laboratory?Monoclonal antibodiesTherapy problems with mouse monoclonal...

  18. BME 695N Lecture 4: Designing "Theragnostic" Systems

    Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuticsA new approach – "theragnostics" (or "theranostics")Examples of current theragnostic…

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  19. BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design

    Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around the consequences of mis-targetingSome ways to lower mis-targeting to non-diseased cells

  20. BME 695N Lecture 2: Basic Concepts of Nanomedical Systems

    Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control system to control drug dosing Elements of good engineering designWhenever possible, use a general design...

  21. BME 695N Lecture 1: Need for New Perspectives on Medicine

    Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseIdentification of the "diseased state"Simple measurements of body structure and functionFollow-up...

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ABOUT THIS SHOW

This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...

HOSTED BY

James Leary

Produced by nanoHUB.org

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007) currently has 21 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.

What is [Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007) about?

This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007) has 21 episodes. Check the episode list to see recent publication dates and frequency.

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