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BME 695N Lecture 7: Normal & facilitated cell entry mechanisms episode artwork

Sep 16, 2007

BME 695N Lecture 7: Normal & facilitated cell entry mechanisms

from [Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007) Hosted by James Leary

Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cellsReceptor mediated uptakeReceptor mediated transport of desired moleculesExample- transferrin receptor transport of iron for metabolismNanoparticle uptakeSize mattersAgglomeration reduces uptakeDrug delivery by "shedding"Extracellular drug delivery by sheddingIntracellular drug release by shedding

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