BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells

Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence and location of nanomedical systemsBelow "optical limit" imagingRequirements on the NMS to have X-ray dense, fluorescent, metallic, or magnetic coresCan you study living cells?Technologies – Advantages and disadvantagesFlow cytometry – a "zero order" imaging deviceScanning and Transmission electron microscopyConfocal microscopy – one and two-photonSurface Plasmon Resonance (SPR) ImagingAtomic Force MicroscopyMagnetic Sorting/MRI contrast agents for in-vivo imaging