Chronic lymphedema may not just be about fluid. It may be about cholesterol. 🧬

Chronic lymphoedema may not just be about fluid. It may be about cholesterol. 🧬   In human tissue and translational mouse models, impaired lymphatic drainage led to excess dermal cholesterol deposition, adipocyte dysfunction, fibrosis, and swelling — even when plasma cholesterol was normal.   Clearing tissue cholesterol with cyclodextrin restored lymphatic architecture and reduced oedema.   Clear the cholesterol. Restore the flow