CKM Syndrome Shapes Atrial Fibrillation Outcomes 04/13/26

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like sex differences and adverse clinical outcomes. Key takeaway: CKM Syndrome Shapes Atrial Fibrillation Outcomes. Article Links: Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. (ESC heart failure) Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. (Heart rhythm) Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. (International journal of cardiology) Article 5: Plasma Protein Profiles in Different Heart Failure Phenotypes. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/ckm-syndrome-shapes-atrial-fibrillation-outcomes-04-13-26/ Featured Articles Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967784 Summary: This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41966525 Summary: This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967772 Summary: This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics, laboratory markers, and echocardiographic parameters to identify sex-specific risk factors and predictors. Article 5: Plasma Protein Profiles in Different Heart Failure Phenotypes. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Transcript Today’s date is April 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. Article number two. Plasma Protein Profiles in Different Heart Failure Phenotypes. This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Article number three. Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. Article number four. Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics, laboratory markers, and echocardiographic parameters to identify sex-specific risk factors and predictors. Article number five. Plasma Protein Profiles in Different Heart Failure Phenotypes. This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Thank you for listening. Don’t forget to subscribe. Keywords sex differences, adverse clinical outcomes, plasma protein profiles, U. K. Biobank, stent-based angioplasty, immune checkpoint inhibitor-related myocarditis, six-minute walk distance, echocardiographic parameters, hemodynamics, heart failure, E. U. R. O. bservational Research Programme, atrial fibrillation, in-stent restenosis, risk factors, cardiovascular-kidney-metabolic syndrome, peripheral pulmonary artery stenosis, biomarkers, K. A. F. Registry, myocardial infarction. About Concise summaries of cardiovascular research for professionals. 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