🧠🌊 Clearing the Brain: CSF Flow, Sleep, and Neuroimmunity

🧠💧 How does the brain clean itself—and defend itself?   A landmark Neuron review unifies two once-separate stories: brain waste clearance and immune surveillance. The glymphatic system, powered by CSF flow, sleep, and vascular pulsatility, works hand-in-glove with meningeal lymphatics to clear toxins (β-amyloid, tau) and present brain antigens to the immune system.   💤 Sleep is not rest—it's maintenance. 🛡️ Clearance is not plumbing—it's immunity in motion. 🧠 When this system falters, neurodegeneration follows.   A must-read for anyone interested in sleep, Alzheimer's disease, neuroimmunology, and brain health. 📘 Neuron, 2025.