Creating an environment specific to your epigenome | Dr. Sara Pugh

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1. Ways to reach out to Dr. Pugh
   1. https://sarapughleeds.co.uk/
   2. https://www.facebook.com/busysuperhuman
   3. https://twitter.com/spugh01
2. Sara’s Background
   1. Bachelor's in biochemistry and genetics
   2. Master in bioinformatics
   3. PhD in molecular mechanisms
   4. 10 years lab experience
3. Her Niche is on optimizing the environmental impact on our DNA
   1. An Epigenome is like lights… we determine which ones turn on / express
   2. Lifestyle, diet,
   3. DNA is the music, Epigenome is the piano player
4. Gene Expression control exaples
   1. MTOR is switched on when eating, turned off when fasting
   2. We need both in order to optimize autophagy
5. The process of detox is 4 phases
   1. The idea is to get toxins out of your cells then out of your body
   2. Take ALA, wait half an hour
   3. Take the binders - Benzonite Clay, Charcoal, Zeolite or Chlorella
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6. For Metals - ortho Solicic Acid
   1. https://www.amazon.com/dp/B00LPJLW8E?ref_=cm_sw_r_cp_ud_dp_CV4YH7J87HQ2QE3ZWSDW
7. Blood test panel if 16 metals with ratios
   1. Quicksilver metals panel
   2. https://www.quicksilverscientific.com/mercury-tri-test/
8. Sara’s Approach to diagnosing nutritionally impacted emotional and wellbeing disorders
   1. Measure and address blood sugar
      1. E.g. Remove processed foods
   2. Look for foods that ‘may’ cause inflammation
      1. E.g. Gluten sensitivity
   3. Leaky Gut testing
      1. May be triggered from alcohol
   4. Women over 40 are more sensitive to histamines
   5. Generally takes 3 weeks to see results
   6. BDNF -  brain-derived neurotropic factor, 
      1. a known antidepressant, and that's why a ketogenic diets or fasting, or just beginning to exercise more can help people on their mental health.
9. Why a 72 hour fast is a big win for your health
10. Blood sugar spikes impact emotions
11. Wearing a continuous glucose monitor can help you find both stressful impacts and find foods that you may not suspect are impacting your blood sugar.
    1. Dr. Pugh found out that dark chocolate impacted her blood sugar
12. Getting your blood sugar back under control can take 48 hours
13. There are 7 names for sugar in foods
14. Food companies leverage the ‘magic ratio’ to make snacks addictive
    1. The fructose interferes with the leptin receptor in the brain, which is linked to satiety. That's why, you know, once you start a packet of cookies, it's really hard to stop
15. Sugar is often our first addiction in life.  
16. Dr Pugh’s focuses on movement, mobility and muscle balance
    1.  Social cohesion is an important aspect of total health
    2. She recommends a ‘mix’ of age groups and a

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