🧬 CRISPR dCas9 Activation Systems for Gene Regulation | GeneInCell | 2025

from GeneInCell · host Vinod Reddy Lekkala

How do you turn genes on with CRISPR—without making a single cut? This episode breaks down dCas9-based activators (VP64, p300, SAM, VPR, SunTag), guide design near promoters/enhancers. We compare strengths, limits, and off-target risks. Clear takeaways on assays (qPCR, RNA-seq, ATAC-seq, reporter readouts), durability, and safety considerations for translational work. Educational only; not medical advice.

Episode metadata supplied by the publisher feed · Published Oct 5, 2025

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🧬 CRISPR dCas9 Activation Systems for Gene Regulation | GeneInCell | 2025

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