PODCAST · science
GeneInCell
by Vinod Reddy Lekkala
GeneInCell-The AI-powered Biotech Podcast focuses on crisp, science-based podcasts on stem cells, organoids, and gene editing—tracking breakthroughs from bench to bedside for better human health, including Biotech and business.
Episodes
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Optogenetics Wins the 2026 Nobel Prize- Controlling the Brain with Light | GeneInCell | 2026
Optogenetics has transformed neuroscience by letting scientists control specific nerve cells with light. In this episode, we explore the discoveries behind the 2026 Nobel Prize in Physiology or Medicine, how light-sensitive ion channels became powerful tools for mapping brain circuits, and how...
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AlphaGenome: Finding Disease in the Dark Genome | GeneInCell | 2026
AlphaGenome Atlas is helping decode the 98% of the human genome that doesn’t code for proteins. By predicting how non-coding variants affect transcription, splicing, chromatin accessibility, and gene regulation, it can prioritize potentially harmful mutations, clarify rare disease cases, and…
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Can mRNA Vaccines Fight Cancer? | GeneInCell | 2026
Can mRNA vaccines train the immune system to recognize and attack cancer? In this episode, we explore how mRNA cancer vaccines are designed, how they deliver tumor-specific instructions to immune cells, and why personalized neoantigen vaccines are gaining attention. We also cover current clinical...
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Anti-Aging Peptides- Can We Slow the Biology of Aging? | GeneInCell | 2026
Can peptides help slow the biological processes of aging? In this episode, we explore how anti-aging peptides may influence cellular repair, inflammation, metabolism, collagen production, and tissue regeneration. We examine the scientific evidence, emerging therapeutic applications, and the...
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The Cellular Clock: Telomerase and the Science of Slowing Aging | Longevity | GeneInCell
Telomerase helps protect the ends of chromosomes, but its role in aging is complex. In this episode, we explore how telomeres influence cellular lifespan, whether activating telomerase could slow age-related decline, and the scientific and safety challenges that stand between promising research…
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Can Epigenetic Reprogramming Reverse Aging? | GeneInCell | 2026
Epigenetic reprogramming is emerging as one of the most intriguing ideas in aging research—the possibility that aging is not just damage, but also a reversible loss of cellular identity. In this episode, we explore how scientists are trying to reset the epigenetic instructions that control gene...
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Chemical Antibodies: How Aptamers Could Transform Future Therapies | GeneInCell | 2026
Aptamers are emerging as powerful “chemical antibodies” that can bind targets with high precision while offering advantages in design, synthesis, and stability. In this episode, we explore how these short nucleic acid ligands are selected, how they work, and why they are gaining attention as...
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Antisense Oligonucleotides: Programming RNA to Silence Disease | GeneInCell | 2026
Antisense oligonucleotides are redefining medicine by programming RNA to silence disease at its source. In this episode, we explore how these short, sequence-designed molecules bind target RNA to reduce harmful protein production, reshape splicing, and open new possibilities for precision...
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Silencing Genetic Disease with shRNA | GeneInCell | 2026
shRNA is a gene-silencing tool that uses the cell’s own RNA interference machinery to reduce harmful protein production. In this episode, we explore how short hairpin RNAs are designed to target specific mutant genes, how they are delivered into cells, and why they hold promise for treating…
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Base Editing- Rewriting DNA One Letter at a Time | GeneInCell | 2026
Base editing is changing the future of gene editing by allowing scientists to rewrite DNA one letter at a time. In this episode, we explore how base editors work, why they offer a more precise alternative to traditional CRISPR cutting, and how they are being used to correct disease-causing...
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siRNAs: Programmable Drugs for Silencing Genetic Disease | GeneInCell
siRNAs are transforming medicine by acting as programmable drugs that selectively silence disease-causing genes. In this episode, we explore how small interfering RNAs work through the RNA interference pathway, why they are so powerful for precision therapeutics, and how they are being developed…
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Prime editing: Search and replace for human DNA | GeneInCell | 2026
Prime editing is a next-generation gene editing tool designed to precisely rewrite DNA—like a search-and-replace function for the human genome. In this episode, we break down how prime editing works, the chemistry behind it, and why it offers a powerful alternative to traditional CRISPR by making...
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New Approach Methodologies (NAMs) for Replacing Animal Models in Drug Discovery | GeneInCell | 2026
NAMs are changing how new drugs are developed. We discuss organoids, tissue chips, and AI-based tools, along with the growing FDA and NIH push toward more human-relevant methods that can improve prediction, reduce reliance on animal models, and help bring safer treatments forward faster.
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Growing replacement kidneys from stem cells | GeneInCell | 2026
Can we grow new kidneys from stem cells? In this episode, we explore how scientists are using pluripotent stem cells to create kidney organoids that mimic early kidney development. We discuss how these mini-organs help study kidney disease, test new drugs, and move us closer to future…
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Is Space Travel Safe For You? | GeneInCell | 2026
What really happens to your cells under stress, in space, and during space travel? In this episode, we zoom in on the physiological, cellular, and molecular levels to uncover how zero gravity affects them.
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Growing Beating Human Hearts in a Dish | Heart Organoids | GeneInCell
What does it take to grow a beating human heart in the lab? This episode explores cardiac organoids—self-organizing heart tissues derived from human stem cells that contract, respond to drugs, and model human heart disease. We unpack how iPSCs are guided into cardiac lineages, how electrical and...
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The AI Revolution in Healthcare: 2026 Innovation and Trends | GeneInCell | 2026
In this episode, we explore the AI revolution in healthcare and what 2026 could look like—from smarter diagnostics and personalized treatments to automation that reshapes clinical workflows. We break down the key innovations, emerging trends, and real-world impact of AI on patients, clinicians…
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Engineering the Next Wave of Innovation with Synthetic Biology | GeneInCell | 2026
Synthetic biology is turning cells into programmable factories, sensors, and therapies. In this episode, we explore how DNA can be engineered like code to build smarter medicines, sustainable biomaterials, and living devices—and what it will take to move these innovations from the lab to the real...
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Engineering Blood Vessels for Human Mini Brains | Vascularized Human Brain Organoids | GeneInCell | 2026
How do you give “mini-brains” a bloodstream? This episode explores vascular brain organoids—cerebral organoids engineered with endothelial cells, pericytes, and astrocytes to form BBB-like barriers, improve oxygen/nutrient delivery, and accelerate neuronal maturation. We cover why perfusion…
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Growing Biological Computers-Brain Organoids From Human Cells | GeneInCell
Brain organoids are self-organizing “mini-brains” grown from human stem cells that recapitulate key aspects of early neural development. They fire neural networks on MEAs, model neurodevelopmental and neurodegenerative diseases, and offer human-relevant platforms for drug discovery, circuit...
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Building the Human Gut in a Dish From Pluripotent Stem Cells | GeneInCell | 2026
Grow a “mini-gut” from stem cells—fast. This episode maps the journey from pluripotent cells to functional intestinal organoids, covering key signals (Activin A, Wnt3a/R-spondin, EGF), culture formats (3D domes vs. monolayers), and core readouts (TEER, permeability, metabolism). We highlight use...
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Intestinal 3D Organ Models: Organoids for Drug Testing
Discover how 3D intestinal organoids—mini-gut tissues grown from stem cells—are transforming preclinical drug testing. We break down how these models capture human barrier function, absorption, metabolism, and host–microbiome interactions better than animal systems, enabling smarter toxicity...
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DNA Is Binary Code and Logic | GeneInCell | 2025
DNA as code, cells as computers. We explore how binary models of genomes reveal mutational logic, why evolution mirrors open-source development, and how this lens powers DNA data storage, biomolecular logic gates, and smarter synthetic biology.
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DNA Storage: Encoding Digital Data in Nature's Code | GeneInCell
Silicon is hitting its limits—and our data keeps exploding. In this episode, we explore DNA as a radical new archive: a medium with hyper-dense capacity and millennia-scale stability that doesn’t need power to preserve information. We unpack the workflow—encoding 1s and 0s into A, T, C, and G;...
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CRISPR–Cas9 Variants for High-Fidelity Genome Editing
Explore the shift from standard Cas9 nuclease—which makes double-strand breaks—to precision tools like Cas9 nickases (single-strand “nicks”) and dead Cas9 (binding without cutting). We break down how these variants reduce off-target indels and enable safer editing and gene regulation (CRISPRi/a,...
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Human Liver Organoids- From Stem Cells to Therapies
From stem cells to therapies, this episode dives into the world of human liver organoids—how iPSCs are guided into functional “mini-livers,” the bioengineering tricks that mature them, and the breakthroughs they enable in disease modeling, drug screening, and precision hepatology. In this short...
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PiggyBac Transposons-A Switchable, High-Capacity Gene Delivery System in Living Cells
How PiggyBac moves DNA in—and out—without scars. We cover transposase mechanics (TTAA-site integration and footprint-free excision), large cargo delivery (tens to ~100 kb), and why it’s popular for iPSCs, stable cell lines, and cell therapies.
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Vascularization, Immune Cells, Organoids and Organ-On-Chip | GeneInCell | 2025
A quick tour of next-gen models that add functional vascularization and immune cells to boost physiological relevance. And strategies (self-assembly, pre-patterning) to build perfusable microvascular networks for real maturation. Educational only; not medical advice.
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Eyes In a Dish | Modeling Retinal Development with Pluripotent Stem Cells
How lab-grown mini-retinas model human vision. In this episode, we show how iPSC-derived retinal organoids form layered photoreceptors, enable gene-editing tests (CRISPR, ASOs), and accelerate drug screening for inherited retinal diseases. Clear takeaways, visuals, and translational notes for…
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Nobel Winning Breakthrough: Unpacking Peripheral Immune Tolerance | GeneInCell
How FOXP3-defined Tregs prevent autoimmunity and shape therapy. We trace the discoveries by Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, unpack Treg biology and assays, and explore translational angles—from autoimmune disease and transplantation to cancer immunotherapy and engineered...
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🧬 CRISPR dCas9 Activation Systems for Gene Regulation | GeneInCell | 2025
How do you turn genes on with CRISPR—without making a single cut? This episode breaks down dCas9-based activators (VP64, p300, SAM, VPR, SunTag), guide design near promoters/enhancers. We compare strengths, limits, and off-target risks. Clear takeaways on assays (qPCR, RNA-seq, ATAC-seq, reporter...
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Gene Knockout: From Lab to Therapy | GeneInCell | 2025
In this episode, we explore how turning off defective genes is becoming a crucial aspect of modern medicine. Educational only; not medical advice.
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Antisense Oligonucleotides: From Sequence to Therapy
Dive into the fascinating world of antisense oligonucleotides (ASOs) with this insightful podcast series. Explore the journey from genetic sequencing to groundbreaking therapeutic applications, uncovering how these innovative molecules are transforming the treatment of genetic disorders and…
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AI's Impact on Biology and Drug Discovery | GeneInCell | 2025
How modern AI is rewiring the life-science stack—from target discovery to first-in-human. This episode unpacks foundation models for proteins/RNAs, generative chemistry, AI-guided ADMET/PK, phenotypic screening on organoids with high-content imaging, multi-omics integration, and self-driving labs...
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Spaceflight vs. Your Body- Why Vision Suffers
This episode spotlights Spaceflight-Associated Neuro-Ocular Syndrome (SANS)—a major risk where microgravity-driven fluid shifts raise eye/brain pressure, leading to optic nerve swelling and vision changes. Beyond SANS, we examine the full spectrum of space eye hazards: corneal abrasions from...
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The American Biotech Landscape: Investment, Innovation, and Hubs
We map the transition of science into companies in the USA. Hear how funding cycles, NIH/SBIR grants, talent pipelines, universities, CDMOs, and clinical-trial access shape each hub. Educational only; not investment advice.
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Microgravity and Human Health: Risks, Benefits, and Spaceflight Hazards
What does space do to the body—and how can it advance medicine? We break down microgravity’s risks (fluid shifts/SANS, bone loss, muscle atrophy, cardiovascular deconditioning, immune dysregulation, radiation exposure) , then explore benefits for biotech: protein crystallization, stem-cell…
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mRNA Vaccine Research and Therapeutic Applications
Sources trace mRNA tech from basics to bedside: nucleoside-modified mRNA tames innate sensing and boosts translation; engineering across cap/UTRs/poly(A) plus purification optimizes stability and reduces immune noise. Lipid nanoparticles—especially ionizable lipids—are the enabling delivery…
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Personalized CRISPR Gene Therapy: A Medical Breakthrough | 2025
This podcast discusses how CRISPR gene-editing technology is revolutionizing healthcare by making personalized gene therapy a reality. From treating genetic disorders to unlocking precision medicine, CRISPR could transform the way we fight disease.
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CRISPR-GPT: AI Automation for Gene-Editing Experiments
Performing successful CRISPR-Cas9 experiments isn’t just about cutting DNA—it requires precision, programming, and a deep understanding of both the technology and the biology behind it.That’s where CRISPR-GPT comes in: a DNA programming assistant built in Python for automating and optimizing...
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CAR T-Cell Therapy: Unleashing Your Body's Army Against Cancer and Beyond
How reprogrammed T cells become living medicines. In clear, science-first episodes, we trace collection → engineering → infusion, highlight successes in B-cell cancers (CD19, BCMA), unpack risks (CRS, ICANS), and preview what’s next—off-the-shelf/allogeneic CARs, safety switches, and solid-tumor...
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Organoids: Growing the Future of Medicine in Your Hand
Organoids: Growing the Future of Medicine in Your Hand explores how mini-organs built from stem cells are reshaping drug discovery, disease modeling, and regenerative medicine today.
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Frequently Asked Questions
How many episodes does GeneInCell have?
GeneInCell currently has 42 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is GeneInCell about?
GeneInCell-The AI-powered Biotech Podcast focuses on crisp, science-based podcasts on stem cells, organoids, and gene editing—tracking breakthroughs from bench to bedside for better human health, including Biotech and business.
How often does GeneInCell release new episodes?
GeneInCell has 42 episodes. Check the episode list to see recent publication dates and frequency.
Where can I listen to GeneInCell?
You can listen to GeneInCell on PodParley by clicking any episode. We provide an embedded audio player for direct listening, and you can also subscribe via your preferred podcast app using the RSS feed.
Who hosts GeneInCell?
GeneInCell is created and hosted by Vinod Reddy Lekkala.
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