Cytokine-Induced Neurogenesis for Bipolar Disorder: A Case Study

ABSTRACT Bipolar disorder (BPD), formally called manic depression, is a mental health condition that causes extreme mood swings for which specific brain pathology has not yet been precisely defined. We administered cytokine-induced neurogenesis treatment to a 60-year-old male BPD patient to regenerate GABAergic neurons as well as glutamatergic neurons, which resulted in a successful regeneration of the atrophied hippocampus and disorganized cortical structures of the prefrontal cortex and anterior cingulate cortex, which was associated with improved emotional control and the resolution of electrophysiological abnormalities. To the best of Äsl201Äslmult0 our knowledge, this is the first case report demonstrating that cytokine-induced GABAergic and glutamatergic neurogenesis repairs brain pathology due to BPD and improves emotional control.