Cytokine-Induced Neurogenesis in Charcot-Marie-Tooth neuropathy with Connexin 32 Gene Mutation

Charcot-Marie-Tooth (CMT) neuropathy is one of the most common neuromuscular disorders. Despite the identification of more than 100 causative genes, there are few therapeuticoptions are still missing. We present the case of a 66-yeayear-old man carrying a CMT mutation in the connexin 32 gene andwith the APOE genotype ε4/ε3, has symptom who hadhad exhibited symptoms of slowly progressive muscle weakness and atrophy in the hands and feet and recently developed memory impairment.　 The symptomsymptoms of muscle weakness, motor dysfunctions, and memory impairment symptoms were significantly improved by cytokine-induced neurogenesis combined with physical wave therapy by with Arbitrary Waveform Generator (AWG). We discuss here an arbitrary waveform generator (AWG). Here, we discuss the possible mechanistic basis of how this new treatment ameliorates the symptomsymptoms of CMT and propose the a novel clinical application for the treatment ofstrategy for CMT