大家都知道CAR-T,今天3分钟我们来聊聊CAR-NK episode artwork

EPISODE · Oct 9, 2025 · 5 MIN

大家都知道CAR-T,今天3分钟我们来聊聊CAR-NK

from 源于细胞BioInsid的个人播客

这项发表于 2025 年10月8日《Nature Communications》的研究由麻省理工学院与哈佛大学 Dana-Farber 癌症研究所团队完成,核心突破在于通过选择性敲低 HLA-A/B/C 基因、保留 HLA-E 表达,并引入 PD-L1 或单链 HLA-E(SCE),让供体来源的 CAR-NK 细胞在体内实现“免疫隐身”,既不被宿主 T 细胞清除,也避免被宿主 NK 细胞攻击。研究结果显示,这种“隐身型”CAR-NK 细胞在体外的免疫排斥率由约 80% 降至 10%,抗肿瘤杀伤能力提升约 70%,前往小宇宙评论区与主播互动

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大家都知道CAR-T,今天3分钟我们来聊聊CAR-NK

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