Dapagliflozin Before the Cardiac Surgery: Kidney Protection in Four Doses

🫀💊 Can 4 doses help protect the kidney after cardiac surgery? MERCURI-2 randomized 784 patients to perioperative dapagliflozin or placebo. AKI within 7 days fell from 52% to 28%—RR 0.54, an absolute reduction of ~24% and NNT ≈4. 📉 Intriguingly, the signal was driven largely by urine-output–defined AKI; creatinine-only AKI was unchanged. Hard 30-day outcomes were also unchanged. 🎙️ A provocative new chapter in perioperative cardiorenal protection. 🛡️