Detangle with Dr Sanat Phatak

Dr. Sanat Phatak, a clinical immunologist and rheumatologist, joins us for a fascinating deep dive into the complex relationship between our mental state and immune function. We explore the nuanced ways stress impacts immunity—revealing that while chronic stress can suppress certain immune functions, it can paradoxically promote inflammation elsewhere. Dr. Sanat explains that it's a two-way street: inflammation itself can suppress mood and cognitive ability, creating a feedback loop that connects our psychological and physical health. The conversation illuminates the remarkable concept of "immune memory"—how individual cells remember past encounters with pathogens and respond more efficiently when those threats return. Dr. Sanat suggests this cellular memory system may be even more impressive than neurological memory, evolving earlier and functioning without a centralized organ. This mechanism underpins vaccination and explains why exposing ourselves to a wider variety of antigens strengthens our immune response. We tackle common misconceptions about "boosting immunity," with Dr. Sanat challenging the notion that immune health works like muscle building. Instead, he emphasizes that balance is key—not too little, not too much—and that consistent sleep, regular exercise, and proper nutrition trump trendy supplements. Throughout our conversation, we see how the lines between mental and physical health blur, highlighting the importance of validating patients' experiences and addressing health through an integrated lens. Whether you're curious about how social media affects your immune system or wondering if those "immunity boosters" actually work, this episode offers evidence-based insights that will transform how you think about your body's defense system. Follow on Instagram @detangle_by_kinjal