第2649期:Obesity Drugs Not Linked to Suicidal Thoughts(2)

Researchers compared nearly 53,000 Wegovy patients to the same number of closely matched users of other weight-loss drugs. 研究人员将近53,000名Wegovy患者与其他减肥药物的密切匹配使用者进行了比较。They found that during the first six months of use, first-time suicidal thoughts were reported by 0.11 percent of Wegovy users. That is compared to 0.43 percent of users of other drugs that do not belong to the same class as semaglutide. 他们发现，在使用的前六个月中，有0.11％的Wegovy用户报告了首次自杀念头。 相比之下，有0.43％的其他药物的用户与semaglutide不属于同一类。 After taking other risk factors into consideration, the risk of first-time suicidal thoughts was 73 percent lower with Wegovy, the researchers said. 研究人员说，在考虑了其他风险因素之后，Wegovy首次自杀念头的风险降低了73％。 No patient in the Wegovy group reported a suicide attempt, compared to 14 users of the other drugs, the report said. 报告说，Wegovy组中没有患者报告自杀企图，而其他药物的14种使用者。 Among patients with a history of suicidal thoughts, the risk of recurring suicidal thoughts was 56 percent lower with Wegovy than other weight-loss medicines.在有自杀思想史的患者中，与其他减肥药物相比，Wegovy的反复自杀思想的风险低56％。 Similar patterns were seen for use of Ozempic compared with other diabetes drugs. 与其他糖尿病药物相比，观察到使用Ozempic的类似模式。 The findings were consistent no matter the patients’ sex, age, or ethnicity for both semaglutide types, the researchers found. 研究人员发现，无论患者两种类型的患者的性别，年龄或种族如何，这些发现都是一致的。 Such a study cannot prove that GLP-1 agonists do not increase the risk of suicidal ideation. But the findings may reduce concerns. 这样的研究无法证明GLP-1激动剂不会增加自杀意念的风险。 但是这些发现可能会减少关注点。 The researchers were unable to assess the statistical significance of differences in actual suicide attempts. The researchers noted that suicide attempts are "critically different from suicidal ideations." 研究人员无法评估实际自杀企图差异的统计意义。 研究人员指出，自杀企图“与自杀意念截然不同”。 Pamela Davis is a professor at Case Western Reserve School of Medicine in Ohio. She was one of the writers of the study. She said the growth in popularity of Ozempic makes it very important “to understand all its potential complications.”帕梅拉·戴维斯（Pamela Davis）是俄亥俄州凯斯（Case Western Reserve）医学院的教授。 她是研究的作者之一。 她说，Ozempic的受欢迎程度的增长使得“了解其所有潜在并发症”非常重要。 Suggestions that the drug may cause suicidal thoughts are not supported by “this very large and diverse population in the U.S.,” Davis added.戴维斯补充说，“美国这个非常大而多样化的人群”的建议不支持引起自杀念头的建议。