Digoxin: 🌍 Ancient Remedy, Modern Evidence, Global Relevance

🫀 Old drug. New evidence. Renewed relevance. Two major JAMA studies published in 2026 revisit the role of digoxin/digitalis glycosides in modern cardiovascular care. 📊 A meta-analysis of 9,013 patients with HFmrEF/HFrEF showed reduced worsening heart failure events without increased mortality. 🌍 The Dig-RHD randomized trial from India demonstrated that digoxin reduced death or worsening heart failure in symptomatic rheumatic heart disease with minimal toxicity. Key message: 💊 Digoxin may still have an important role as affordable adjunctive therapy—especially in resource-limited settings and carefully selected patients. Sometimes the oldest medicines still have new stories to tell. #Cardiology #HeartFailure #Digoxin #RheumaticHeartDisease #JAMA #Digitalis #HFmrEF #HFrEF #GlobalHealth #CardioTwitte