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EPISODE · Oct 5, 2026 · 15 MIN

Does Creatine Actually Work After 60?

from Health After 40 Science · host Vince

Eleven randomized trials. Nearly three decades of research. One 2026 meta-analysis (Yao et al., Frontiers in Nutrition) pooled every high-quality trial of creatine plus resistance training in adults over 60 — and the answer splits the sales pitch in half. In this episode: - Why muscle loss after 60 matters more than most people think (0:43) - How creatine actually works inside the muscle cell (2:53) - What the 11 trials found: strength, muscle mass, and everyday function (4:18) - Where the uncertainty sits — and who these results don't cover (9:32) - What a reasonable person over 60 should actually do (11:41) Bottom line: creatine plus training produced a small, real strength edge versus training alone in generally healthy adults over 60. It did not reliably increase muscle mass or improve everyday physical function in this analysis. The training is the main event; the supplement is at best a small add-on. Educational only — not medical advice. Talk to your clinician before starting or changing any supplement, especially if you have kidney issues or take medication. Source: Yao et al. (2026), "Effects of creatine supplementation combined with resistance training on muscle strength, muscle mass, and physical function in adults aged 60 years and older: a systematic review and meta-analysis," Frontiers in Nutrition. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1919884/full Note: this episode's audio is repurposed from our YouTube deep dive, so you may hear occasional references to on-screen visuals. 🌐 More at https://healthafter40science.com 📚 Books: Health After 40: Strength & Muscle After 40: https://www.amazon.com/dp/B0HKB8DLBP?tag=mywebzamz-20

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Eleven randomized trials. Nearly three decades of research. One 2026 meta-analysis (Yao et al., Frontiers in Nutrition) pooled every high-quality trial of creatine plus resistance training in adults over 60 — and the answer splits the sales pitch in half. In this episode: - Why muscle loss after 60 matters more than most people think (0:43) - How creatine actually works inside the muscle cell (2:53) - What the 11 trials found: strength, muscle mass, and everyday function (4:18) - Where the u...

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Does Creatine Actually Work After 60?

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