Early F.H. Diagnosis Via Newborn Blood Spots 10/30/25

Welcome to Cardiology Today – Recorded October 30, 2025. This episode summarizes 5 key cardiology studies on topics like nitric oxide and Familial hypercholesterolemia. Key takeaway: Early F.H. Diagnosis Via Newborn Blood Spots. Article Links: Article 1: Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. (The New England journal of medicine) Article 2: PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. (Journal of the American College of Cardiology) Article 3: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. (Circulation) Article 4: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. (Circulation) Article 5: Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/early-f-h-diagnosis-via-newborn-blood-spots-10-30-25/ Featured Articles Article 1: Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159879 Summary: This international, investigator-initiated, open-label, randomized controlled trial was designed to compare immediate percutaneous coronary intervention guided by instantaneous wave-free ratio with deferred percutaneous coronary intervention guided by cardiac stress magnetic resonance imaging. The study enrolled patients with S.T.-segment elevation myocardial infarction and multivessel disease. This research establishes a robust methodology to determine the optimal timing for treating nonculprit lesions in these high-risk patients. The findings from this trial will provide critical evidence to guide clinical practice for nonculprit-lesion management in S.T.-segment elevation myocardial infarction. Article 2: PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159978 Summary: The PROCTOR multicenter randomized trial was designed to compare clinical outcomes between percutaneous coronary intervention of the native coronary artery versus percutaneous coronary intervention of the saphenous vein graft. This study enrolled patients with prior coronary artery bypass grafting who presented with saphenous vein graft failure. This randomized comparison directly addresses a gap in current guidelines, which rely solely on observational data for recommendations regarding percutaneous coronary intervention strategy after bypass surgery. The findings will establish evidence-based guidance for optimal revascularization in this complex patient population. Article 3: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159282 Summary: This research assessed the role of nuclear endothelial nitric oxide synthase and nitric oxide signaling for endothelial cell function. Using loss-of-function approaches, confocal microscopy, and biochemical analyses, the study found that endothelial nitric oxide synthase localized in the endothelial cell nucleus generates nitric oxide. This nuclear endothelial nitric oxide synthase interacts with and S-nitrosates Adenosine Deaminase, R.N.A.-Specific, 1, consequently modulating type I interferon signaling. These findings reveal a novel molecular mechanism through which nuclear endothelial nitric oxide synthase regulates vascular inflammation and endothelial homeostasis, offering new therapeutic avenues for endothelial dysfunction. Article 4: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159251 Summary: This retrospective cohort study characterized the geometric features of viable corridors participating in ventricular tachycardia circuitry in ischemic cardiomyopathy. Researchers analyzed patients who underwent cardiovascular magnetic resonance imaging before their first ventricular tachycardia ablation. Applying a 3-dimensional hyperboloid model to viable corridors derived from late gadolinium enhanced cardiovascular magnetic resonance imaging, the study provided a precise geometric understanding of ventricular tachycardia circuitry. This detailed geometric mapping improves the understanding of ventricular tachycardia mechanisms, potentially leading to more targeted and effective ablation strategies for ischemic cardiomyopathy. Article 5: Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots. Journal: JAMA cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41160044 Summary: This cross-sectional study investigated the feasibility and results of genetic testing for familial hypercholesterolemia using residual newborn screening dried blood spots. The research successfully performed genetic testing in samples with biomarkers suggesting high risk for familial hypercholesterolemia. This approach demonstrates a viable method for dramatically increasing the early diagnosis of familial hypercholesterolemia in newborns and their relatives. These findings establish a crucial initial step toward developing a multitier newborn screening program for this common, treatable genetic condition, enabling earlier intervention and improved long-term outcomes. Transcript Today’s date is October 30, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Immediate or Deferred Nonculprit-Lesion Percutaneous Coronary Intervention in Myocardial Infarction. This international, investigator-initiated, open-label, randomized controlled trial was designed to compare immediate percutaneous coronary intervention guided by instantaneous wave-free ratio with deferred percutaneous coronary intervention guided by cardiac stress magnetic resonance imaging. The study enrolled patients with S.T.-segment elevation myocardial infarction and multivessel disease. This research establishes a robust methodology to determine the optimal timing for treating nonculprit lesions in these high-risk patients. The findings from this trial will provide critical evidence to guide clinical practice for nonculprit-lesion management in S.T.-segment elevation myocardial infarction. Article number two. Percutaneous Coronary Intervention of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. The PROCTOR multicenter randomized trial was designed to compare clinical outcomes between percutaneous coronary intervention of the native coronary artery versus percutaneous coronary intervention of the saphenous vein graft. This study enrolled patients with prior coronary artery bypass grafting who presented with saphenous vein graft failure. This randomized comparison directly addresses a gap in current guidelines, which rely solely on observational data for recommendations regarding percutaneous coronary intervention strategy after bypass surgery. The findings will establish evidence-based guidance for optimal revascularization in this complex patient population. Article number three. Nuclear Endothelial Nitric Oxide Synthase Interacts With and S-Nitrosates Adenosine Deaminase, R.N.A.-Specific, 1 to Modulate Type I Interferon Signaling and Endothelial Function. This research assessed the role of nuclear endothelial nitric oxide synthase and nitric oxide signaling for endothelial cell function. Using loss-of-function approaches, confocal microscopy, and biochemical analyses, the study found that endothelial nitric oxide synthase localized in the endothelial cell nucleus generates nitric oxide. This nuclear endothelial nitric oxide synthase interacts with and S-nitrosates Adenosine Deaminase, R.N.A.-Specific, 1, consequently modulating type I interferon signaling. These findings reveal a novel molecular mechanism through which nuclear endothelial nitric oxide synthase regulates vascular inflammation and endothelial homeostasis, offering new therapeutic avenues for endothelial dysfunction. Article number four. Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. This retrospective cohort study characterized the geometric features of viable corridors participating in ventricular tachycardia circuitry in ischemic cardiomyopathy. Researchers analyzed patients who underwent cardiovascular magnetic resonance imaging before their first ventricular tachycardia ablation. Applying a 3-dimensional hyperboloid model to viable corridors derived from late gadolinium enhanced cardiovascular magnetic resonance imaging, the study provided a precise geometric understanding of ventricular tachycardia circuitry. This detailed geometric mapping improves the understanding of ventricular tachycardia mechanisms, potentially leading to more targeted and effective ablation strategies for ischemic cardiomyopathy. Article number five. Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots. This cross-sectional study investigated the feasibility and results of genetic testing for familial hypercholesterolemia using residual newborn screening dried blood spots. The research successfully performed genetic testing in samples with biomarkers suggesting high risk for familial hypercholesterolemia. This approach demonstrates a viable method for dramatically increasing the early diagnosis of familial hypercholesterolemia in newborns and their relatives. These findings establish a crucial initial step toward developing a multitier newborn screening program for this common, treatable genetic condition, enabling earlier intervention and improved long-term outcomes. Thank you for listening. Don’t forget to subscribe. Keywords nitric oxide, Familial hypercholesterolemia, dried blood spots, multivessel disease, S.T.-segment elevation myocardial infarction, newborn screening, late gadolinium enhancement, Coronary artery bypass grafting, P.C.I., ablation, Ventricular tachycardia, type I interferon signaling, revascularization, cardiac M.R.I., vascular inflammation, instantaneous wave-free ratio, F.H., genetic diagnosis, saphenous vein graft, ischemic cardiomyopathy, native coronary artery, A.D.A.R.1., endothelial function, nonculprit lesion, 3-dimensional mapping, Endothelial nitric oxide synthase. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Early F.H. Diagnosis Via Newborn Blood Spots 10/30/25 first appeared on Cardiology Today.