Electrogram Frequency Predicts Ablation Success 09/14/25

Welcome to Cardiology Today – Recorded September 14, 2025. This episode summarizes 5 key cardiology studies on topics like transcatheter closure and cardiac imaging. Key takeaway: Electrogram Frequency Predicts Ablation Success. Article Links: Article 1: Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: cluster analysis of the Murcia AF Project III (MAFP-III). (Heart rhythm) Article 2: Comparison of Far-Field and Peak Frequency Electrogram Characteristics at the Earliest Activation Sites during Idiopathic Ventricular Arrhythmias: A novel index to predict ablation success. (Heart rhythm) Article 3: Changes in Myocardial Light Chain Amyloid Burden After Plasma Cell Therapy. (JACC. Cardiovascular imaging) Article 4: Multiple Amplatzer Vascular Plug III implantation-feasible, safe, and effective for paravalvular leak closure: Results from a single-center registry. (The Canadian journal of cardiology) Article 5: Serial quantitative flow ratio measurements of a successfully recanalized coronary chronic total occlusion. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/electrogram-frequency-predicts-ablation-success-09-14-25/ Featured Articles Article 1: Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: cluster analysis of the Murcia AF Project III (MAFP-III). Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945558 Summary: This prospective study of anticoagulated atrial fibrillation patients identified distinct phenotypic clusters using hierarchical clustering. The clusters were then analyzed for their association with thromboembolic events, major bleeding, major adverse cardiovascular events, cardiovascular death, and all-cause death over two years, providing a framework for phenotype-guided risk stratification in this population. Article 2: Comparison of Far-Field and Peak Frequency Electrogram Characteristics at the Earliest Activation Sites during Idiopathic Ventricular Arrhythmias: A novel index to predict ablation success. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945557 Summary: This retrospective analysis of 111 idiopathic ventricular arrhythmias in 104 patients examined peak frequency analyses of electrograms at the earliest activation site to predict catheter ablation outcomes. The study suggests peak frequency electrogram characteristics can help differentiate near-field from far-field components, potentially improving ablation success by better identifying appropriate ablation targets. Article 3: Changes in Myocardial Light Chain Amyloid Burden After Plasma Cell Therapy. Journal: JACC. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40938234 Summary: This prospective study of 81 patients with biopsy-proven light chain amyloidosis evaluated changes in myocardial amyloid burden following plasma cell-directed chemotherapy using serial cardiac imaging with radiolabeled serum amyloid P component scintigraphy. The study tracked myocardial amyloid fibril burden in patients with and without amyloid cardiomyopathy, seeking to quantify the impact of plasma cell therapy on cardiac amyloid deposits and inform treatment strategies. Article 4: Multiple Amplatzer Vascular Plug III implantation-feasible, safe, and effective for paravalvular leak closure: Results from a single-center registry. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945911 Summary: This retrospective, single-center registry evaluated the feasibility, safety, and efficacy of using multiple Amplatzer ParaValvular Plug III devices for transcatheter paravalvular leak closure. The study demonstrated that this multi-occluder approach is a reasonable alternative to surgical repair, particularly in high-risk patients experiencing heart failure or hemolysis due to paravalvular leaks. Article 5: Serial quantitative flow ratio measurements of a successfully recanalized coronary chronic total occlusion. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40945616 Summary: This retrospective study assessed functional results measured by quantitative flow ratio immediately and six months following successful percutaneous coronary intervention of a chronic total occlusion. The study investigated how coronary perfusion changes over time after successful chronic total occlusion percutaneous coronary intervention, which may impact physiological assessment, suggesting QFR can help detect suboptimal results post-procedure. Transcript Today’s date is September 14, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Phenotype-guided risk stratification in anticoagulated atrial fibrillation patients: cluster analysis of the Murcia AF Project III (MAFP-III). This prospective study of anticoagulated atrial fibrillation patients identified distinct phenotypic clusters using hierarchical clustering. The clusters were then analyzed for their association with thromboembolic events, major bleeding, major adverse cardiovascular events, cardiovascular death, and all-cause death over two years, providing a framework for phenotype-guided risk stratification in this population. Article number two. Comparison of Far-Field and Peak Frequency Electrogram Characteristics at the Earliest Activation Sites during Idiopathic Ventricular Arrhythmias: A novel index to predict ablation success. This retrospective analysis of 111 idiopathic ventricular arrhythmias in 104 patients examined peak frequency analyses of electrograms at the earliest activation site to predict catheter ablation outcomes. The study suggests peak frequency electrogram characteristics can help differentiate near-field from far-field components, potentially improving ablation success by better identifying appropriate ablation targets. Article number three. Changes in Myocardial Light Chain Amyloid Burden After Plasma Cell Therapy. This prospective study of 81 patients with biopsy-proven light chain amyloidosis evaluated changes in myocardial amyloid burden following plasma cell-directed chemotherapy using serial cardiac imaging with radiolabeled serum amyloid P component scintigraphy. The study tracked myocardial amyloid fibril burden in patients with and without amyloid cardiomyopathy, seeking to quantify the impact of plasma cell therapy on cardiac amyloid deposits and inform treatment strategies. Article number four. Multiple Amplatzer Vascular Plug III implantation-feasible, safe, and effective for paravalvular leak closure: Results from a single-center registry. This retrospective, single-center registry evaluated the feasibility, safety, and efficacy of using multiple Amplatzer ParaValvular Plug III devices for transcatheter paravalvular leak closure. The study demonstrated that this multi-occluder approach is a reasonable alternative to surgical repair, particularly in high-risk patients experiencing heart failure or hemolysis due to paravalvular leaks. Article number five. Serial quantitative flow ratio measurements of a successfully recanalized coronary chronic total occlusion. This retrospective study assessed functional results measured by quantitative flow ratio immediately and six months following successful percutaneous coronary intervention of a chronic total occlusion. The study investigated how coronary perfusion changes over time after successful chronic total occlusion percutaneous coronary intervention, which may impact physiological assessment, suggesting QFR can help detect suboptimal results post-procedure. Thank you for listening. Don’t forget to subscribe. Keywords transcatheter closure, cardiac imaging, heart failure, amyloid cardiomyopathy, ablation success, thromboembolism, peak frequency, chronic total occlusion, plasma cell therapy, anticoagulation, quantitative flow ratio, atrial fibrillation, Amplatzer ParaValvular Plug III, hemolysis, electrogram, coronary perfusion, physiological assessment, catheter ablation, light chain amyloidosis, ventricular arrhythmia, percutaneous coronary intervention, major bleeding, risk stratification, paravalvular leak, myocardial amyloid burden. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Electrogram Frequency Predicts Ablation Success 09/14/25 first appeared on Cardiology Today.