ElectroPulse PFA: First-in-Human Data 11/17/25

Welcome to Cardiology Today – Recorded November 17, 2025. This episode summarizes 5 key cardiology studies on topics like cardiac phenotype and S. L. C. 6 A. 8 variants. Key takeaway: ElectroPulse PFA: First-in-Human Data. Article Links: Article 1: Prominent U-waves Without QT Prolongation in X-linked Creatine Transporter Deficiency Caused by SLC6A8 Variants. (Heart rhythm) Article 2: Update on First-in-Human Experience of High-Energy ElectroPulse Pulsed Field Ablation. (Heart rhythm) Article 3: Atrioventricular Block After Transcatheter Atrial Septal Defect Closure: Comprehensive Short-term to Long-Term Outcome Analysis. (Heart rhythm) Article 4: Device-Based Longitudinal Monitoring of Premature Atrial Contractions Before Atrial Fibrillation Onset. (Heart rhythm) Article 5: Added diagnostic value of Electrophysiological study in new-onset Left Bundle Branch Block after transcatheter aortic valve implantation. (The Canadian journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/electropulse-pfa-first-in-human-data-11-17-25/ Featured Articles Article 1: Prominent U-waves Without QT Prolongation in X-linked Creatine Transporter Deficiency Caused by SLC6A8 Variants. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242588 Summary: T. Prolongation in X-linked Creatine Transporter Deficiency Caused by S. L. C. 6 A. 8 Variants. Complete results detailing the cardiac phenotype of male Creatine Transporter Deficiency patients were not available in the abstract. This study focused on characterizing cardiac manifestations in patients with S. L. C. 6 A. 8 variants. Early clinical reports had raised concerns regarding possible associations with Q. T. c. prolongation and dilated cardiomyopathy in this patient population. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 2: Update on First-in-Human Experience of High-Energy ElectroPulse Pulsed Field Ablation. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242587 Summary: Complete results, including specific numerical findings for the primary endpoint, were not available in the abstract. This first-in-human study evaluated mid-term outcomes of the ElectroPulse pulsed field ablation system for pulmonary vein and posterior wall isolation. The trial enrolled 60 patients with symptomatic atrial fibrillation, with two cohorts receiving either a standard or a modified ablation protocol. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 3: Atrioventricular Block After Transcatheter Atrial Septal Defect Closure: Comprehensive Short-term to Long-Term Outcome Analysis. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242586 Summary: Complete results detailing the incidence, risk factors, and outcomes of atrioventricular block following transcatheter atrial septal defect closure were not available in the abstract. The study retrospectively analyzed 1954 patients who underwent transcatheter atrial septal defect closure between 1999 and 2020 at three tertiary centers. This comprehensive analysis uniquely focused on providing detailed short-term to long-term follow-up. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 4: Device-Based Longitudinal Monitoring of Premature Atrial Contractions Before Atrial Fibrillation Onset. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242585 Summary: Specific numerical findings regarding the temporal frequency pattern of premature atrial contractions before atrial fibrillation onset were not available in the abstract. This retrospective study utilized long-term monitoring data from cardiovascular implantable electronic devices. It included 101 patients from Boston Scientific devices with a mean follow-up of 5.2 years, divided into groups based on whether they developed atrial fibrillation. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article 5: Added diagnostic value of Electrophysiological study in new-onset Left Bundle Branch Block after transcatheter aortic valve implantation. Journal: The Canadian journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41242385 Summary: Specific numerical findings on the diagnostic value of electrophysiological study in new-onset left bundle branch block after transcatheter aortic valve implantation were not available in the abstract. This prospective multicenter study included 183 patients who developed new-onset left bundle branch block 24 hours or more after transcatheter aortic valve implantation. The research compared His-ventricular intervals with electrocardiogram parameters to assess diagnostic performance for risk stratification. Therefore, no definitive outcomes from this study can be reported based on the abstract. Transcript Today’s date is November 17, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Prominent U-waves Without Q. T. Prolongation in X-linked Creatine Transporter Deficiency Caused by S. L. C. 6 A. 8 Variants. Complete results detailing the cardiac phenotype of male Creatine Transporter Deficiency patients were not available in the abstract. This study focused on characterizing cardiac manifestations in patients with S. L. C. 6 A. 8 variants. Early clinical reports had raised concerns regarding possible associations with Q. T. c. prolongation and dilated cardiomyopathy in this patient population. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article number two. Update on First-in-Human Experience of High-Energy ElectroPulse Pulsed Field Ablation. Complete results, including specific numerical findings for the primary endpoint, were not available in the abstract. This first-in-human study evaluated mid-term outcomes of the ElectroPulse pulsed field ablation system for pulmonary vein and posterior wall isolation. The trial enrolled 60 patients with symptomatic atrial fibrillation, with two cohorts receiving either a standard or a modified ablation protocol. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article number three. Atrioventricular Block After Transcatheter Atrial Septal Defect Closure: Comprehensive Short-term to Long-Term Outcome Analysis. Complete results detailing the incidence, risk factors, and outcomes of atrioventricular block following transcatheter atrial septal defect closure were not available in the abstract. The study retrospectively analyzed 1954 patients who underwent transcatheter atrial septal defect closure between 1999 and 2020 at three tertiary centers. This comprehensive analysis uniquely focused on providing detailed short-term to long-term follow-up. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article number four. Device-Based Longitudinal Monitoring of Premature Atrial Contractions Before Atrial Fibrillation Onset. Specific numerical findings regarding the temporal frequency pattern of premature atrial contractions before atrial fibrillation onset were not available in the abstract. This retrospective study utilized long-term monitoring data from cardiovascular implantable electronic devices. It included 101 patients from Boston Scientific devices with a mean follow-up of 5.2 years, divided into groups based on whether they developed atrial fibrillation. Therefore, no definitive outcomes from this study can be reported based on the abstract. Article number five. Added diagnostic value of Electrophysiological study in new-onset Left Bundle Branch Block after transcatheter aortic valve implantation. Specific numerical findings on the diagnostic value of electrophysiological study in new-onset left bundle branch block after transcatheter aortic valve implantation were not available in the abstract. This prospective multicenter study included 183 patients who developed new-onset left bundle branch block 24 hours or more after transcatheter aortic valve implantation. The research compared His-ventricular intervals with electrocardiogram parameters to assess diagnostic performance for risk stratification. Therefore, no definitive outcomes from this study can be reported based on the abstract. Thank you for listening. Don’t forget to subscribe. Keywords cardiac phenotype, S. L. C. 6 A. 8 variants, premature atrial contractions, left bundle branch block, atrial fibrillation, posterior wall isolation, transcatheter aortic valve implantation, P. A. C. frequency, pulsed field ablation, ElectroPulse system, dilated cardiomyopathy, longitudinal monitoring, electrophysiological study, transcatheter atrial septal defect closure, cardiovascular implantable electronic devices, long-term outcomes, atrial septal defect, atrioventricular block, conduction disturbances, Q. T. c. prolongation, Creatine Transporter Deficiency, His-ventricular interval, pulmonary vein isolation. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post ElectroPulse PFA: First-in-Human Data 11/17/25 first appeared on Cardiology Today.