Engineering Autoimmunity: A New Model for Studying MS Progression and Remyelination

Guest: Christian Cordano, MD, PhD While multiple kinds of animal models are commonly used to study multiple sclerosis (MS), they are not always ideal for getting the full picture of the disease. To address these gaps, a new CAR T-cell-based model provides a reproducible disease course, discrete lesion formation, and an improved platform for testing remyelination therapies. Dr. Christian Cordano, Associate Researcher of Neurology at the University of California, San Francisco Weill Institute for Neurosciences, explains how this approach aims to overcome key limitations of traditional research models for MS. Dr. Cordano also spoke on this topic at the ACTRIMS Forum 2025.