Engineering Blood Vessels for Human Mini Brains | Vascularized Human Brain Organoids | GeneInCell | 2026

How do you give “mini-brains” a bloodstream? This episode explores vascular brain organoids—cerebral organoids engineered with endothelial cells, pericytes, and astrocytes to form BBB-like barriers, improve oxygen/nutrient delivery, and accelerate neuronal maturation. We cover why perfusion matters for MEA activity and drug testing, how microvessels enable neurovascular-coupling studies, and what it will take to scale these tissues for translational neuroscience.