(English) Episode 221-Tendinopathy - The Pain Metabolism Vascular Loop

This 2025 review article examines the complex biological landscape of tendinopathy, a condition marked by rising global prevalence and significant economic costs. The authors describe how tendon tissue, once viewed as relatively inactive, contains a diverse variety of cell populations, including immune-relevant "tenophages." By analyzing extracellular matrix changes, the text highlights how mechanical stress triggers mechanotransduction, converting physical forces into biochemical signals that can drive inflammation or healing. The research explores the interplay between vasculature, lymphatic drainage, and metabolism, suggesting that blood vessel leakiness and high internal pressure contribute to tissue damage. Ultimately, the source advocates for a comprehensive therapeutic approach that addresses the intricate relationships between cellular diversity, mechanical loading, and inflammatory responses.(Gehwolf R, Tempfer H, Cesur NP, Wagner A, Traweger A, Lehner C. Tendinopathy: The interplay between mechanical stress, inflammation, and vascularity. Adv Sci (Weinh) [Internet]. 2025;12(36):e06440. Available from: http://dx.doi.org/10.1002/advs.202506440)