(English) Episode 253-Why morning exercise heals chronic tendon pain

This review examines how the circadian clock serves as a vital regulator of tendon health and the development of tendinopathy. Research in mouse models indicates that a peripheral molecular oscillator controls the daily synthesis and removal of a "chronomatrix," which protects the permanent collagen structure of the tissue. Recent human studies suggest that chronic overuse injuries are associated with a dampened or disrupted internal rhythm, potentially leading to extracellular matrix breakdown. Scientists are now investigating whether timed exercise therapy can effectively resynchronize these tissue clocks to improve clinical outcomes for patients. Ultimately, understanding these biological rhythms may offer new pathways for the early detection and treatment of musculoskeletal disorders.(Møbjerg A, Pedersen SD, Kjaer M, Yeung C-YC. Role of the tendon circadian clock in tendinopathy and implications for therapeutics. Int J Exp Pathol [Internet]. 2025;106(3):e70001. Available from: http://dx.doi.org/10.1111/iep.70001)