Ep. 143 Navigating Upper Tract Urothelial Carcinoma with Dr. Padraic O'Malley

In this episode, host Dr. Jose Silva and Dr. Padraic O’Malley, a urologic oncologist from University of Florida Health, discuss how to diagnose and treat upper tract urothelial carcinoma. Referencing official guidelines and personal experiences, the doctors discuss various treatments such as tumor ablation, JELMYTO, neoadjuvant chemotherapy, and nephroureterectomy. They also discuss the role of lymph node dissection and the significance of Lynch syndrome. Additionally, they touch upon the Thulium laser and updated staging guidelines. The episode concludes with discussions about follow-up care, and the doctors agree on the need for a standardized reporting system and risk stratification guidelines for improved patient management. --- SHOW NOTES 00:00 - Introduction 02:09 - Initial Presentation of Patients with Upper Tract Urothelial Carcinoma 10:54 - Discussion on Lynch Syndrome 14:27 - Risk Stratification in Patients 15:37 - Tumor Ablation and Intracavitary Therapies 26:47 - The Use of Thulium Laser in Treatment 28:50 - Discussion on High Volume Disease 32:39 - Discussion on High Grade Tumors 38:23 - The Role of Neoadjuvant Chemotherapy 43:02 - Post-Treatment Follow Up 45:18 - Standardized Reporting in Guidelines