GU Cast | Urology Podcast
by Professor Declan Murphy & Dr Renu Eapen
A urology podcast, focussing on prostate cancer, kidney cancer, bladder cancer, testis and penile cancer. Join Professor Declan Murphy and Dr Renu Eapen from Peter MacCallum Cancer Centre in Melbourne for this regular dive into the world of genitourinary (GU) Oncology and Urology. Regular guests from all over the world, from every walk of life. Find out more gucast.org
Episodes
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China focus - cardiovascular disease and prostate cancer
Another of our special episodes with our Chinese team. We are joined by our Associate Editor for China, Yige Bao (SCU Hospital Xiamen, Xiamen City), and Junlong Zhang (Drum Tower Hospital, Nanjing), to discuss the topic of cardiovascualr disease in patients starting treatment for advanced…
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Journal Club | Intermittent hormonal therapy and open vs robot cystectomy
Two fantastic topics on the GU Cast Journal Club today. The classic SWOG study of continuous vs intermittent hormonal therapy (NEJM 2013), and the RCT of open vs robotic radical cystectomy (JAMA 2022). Everything you need to bluff your way on these classic papers in a bite-sized podcast, led by…
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#ERUS26 Live Robotic Surgery Spectacular from Padua
A bumper episode bringing you some amazing highlights from the world's top live robotic urology meeting! We are once again at the EAU Robotic Urology Section Annual meeting, this year in Padua, Italy, featuring more than 50 live robotic urology surgeries, a large number of which are international...
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Ben & Sam's robotic surgery tech tour | #ERUS26
Check out Join Ben Challacombe (Guy’s Hospital, London), and Sam Davies (Mater Hospital, Brisbane), as they take Declan Murphy for a tour of the incredible robotic surgery technology at the EAU Robotic Urology Section (ERUS) meeting in Padua. The largest ever collection of robotic surgery devices...
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PLND for prostate cancer | Yes/No/Maybe?! With Briganti and Maurer
Pelvic lymph node dissection (PLND) - one of our perennial favourite and contentious topics on GU Cast. Today we have both Alberto Briganti (Milano, ITA), and Tobias Maurer (Hamburg, GER), in the studio. Two hugely experienced prostate cancer surgeons, both with huge expertise in PLND. Alberto's...
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Journal Club | DETECT haematuria trial and the post-prostatectomy radiotherapy trials
Two great topics on the GU Cast Journal Club today. How should we image patients with haematuria (the DETECT trial, J Urol 2018), and what is the role of adjuvant vs salvage radiotherpay following radical prostatectomy (three great trials - RAVES, RADICALS and GETUG-AFU 17), see links below).…
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Widespread welcome for new Aussie prostate cancer guidelines
The perennially thorny topic of prostate cancer screening has been very well addressed in the brand new Australian guidelines for the Early Detection of Prostate Cancer which we are delighted to highlight today. Pragmatic, progressive and patient-focused, are some of the comments we have read -...
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Advanced prostate cancer in a large urology group practice
Urologist Ben Lowentritt (Chesapeake Urology, Baltimore), pops into the studio today while passing through Melbourne. We chat about life in a large urology group practice (a huge part of urology service delivery in the USA), why there appears to be a drop in interest in Fellowship training, and…
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Journal Club | Randomised surgical trials that did not change practice!
Open vs partial nephrectomy, and open vs robotic prostatectomy - two large randomised trials that did not change surgical practice! Just as important to examine these in GU Cast Journal Club as to examine pivotal trials that did change practice. Today we discuss the EORTC Today we discuss the…
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ARASEC - Rethinking clinical trial design
Welcome back Rana McKay! Renu was on a flight to Europe this week so Rana jumped into her seat in the GU Cast studio this week to have a chat about the intriguing ARASEC trial which she presented at the AUA Annual Meeting recently. Plus her thoughts on the ARACOG data presented at ASCO last…
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Timing, touch & technique: Batting lessons for nerve-sparing radical prostatectomy | With Ash Tewari
Tips and tricks for nerve-sparing surgery, learned over 25 years of performing robotic radical prostatectomy. Today we are joined by Dr Ash Tewari, Chief of Urology at Mt Sinai (New York), to talk about his favourite topic - nerve-sparing surgery - and a little about his second favourite topic -...
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Berlin Masterclass | Advanced prostate cancer
Hot topics in a hot city!! Declan and Renu escaped from deep Winter in Melbourne and landed into the hottest day on record in Berlin!! We are here to help with the Astellas Global Prostate Cancer Masterclass, a wonderful two day meeting focussing on advanced prostate cancer. Delegates from all…
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EV-pembro in localised and advanced bladder cancer - a superb summary!
All you need to know about enfortumab vedotin (EV) & pembro in bladder cancer in 25 minutes! We are joined in studio by bladder cancer gurus Shilpa Gupta (Cleveland Clinic, USA) and Andrew Weickhardt (Austin Health, AUS) to get an update on the role of EV-pembro in both muscle-invasive localised...
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Testis cancer and miR-371 - all you need to know!
Yep it's been a buzz word in testis cancer for a while now, but with the read-out of the CLIMATE and SWOG 1823 trials in the past six months, we thought we better get ourselves updated on this exciting biomarker. We are joined in studio by testis cancer gurus Ben Tran (Medical Oncologist, Peter...
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Journal club #8 | PROTECT and EV-301
Welcome to Episode 8 of our monthly GU Cast Journal Club! Today we focus on two very important papers in localised prostate cancer and metastatic bladder cancer. The landmark 15 year update of the PROTECT trial, published in NEJM in 2023, and the breakthrough EV-301 trial which heralded…
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Bayer Apex comes to Melbourne!
Renu had been to an excellent Bayer Apex meeting in Europe in the past, so was very happy to hear Apex was coming to us for its first Asia-Pacific outing! A wonderful prostate cancer Faculty headlined by Neal Shore, Dan George, Derya Tilki, Fred Saad, Amit Bahl, Tamim Niazi to name but a few…
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Did PROTEUS just change Urology??
Breaking News podcast just after the long-awaited PROTEUS trial reads out at the ASCO Plenary in Chicago! Plus a simultaneous NEJM paper! Huge day for prostate cancer surgery. Declan and Renu are joined by lead author Dr Mary-Ellen Taplin (Dana Farber Cancer Institute & Harvard University), to…
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ARASEC and Lead-in ADT - China focus
Two interesting papers caught the eye of our GU Cast China team this week; the first is the ARASEC trial which Dr Rana McKay read out in the Practice-Changing Plenary at the AUA Annual Meeting in Washington. This is an interesting comparison of ADT + darolutamide for mHSPC in a prospective US...
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Is Copper the new Gold??! Co-PSMA trial in European Urology
Now this is an interesting one, a new PSMA tracer which appears to greatly outperform 68Ga-PSMA-11 for biochemical recurrence. We discuss 64Cu-SAR-bisPSMA with Professor Louise Emmett (Nuclear Medicine Physician, Sydney), and Dr Matt Roberts (Urologist, Brisbane), which they compared head to head...
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EAU Prostate Cancer Guideline Update
One of our most popular podcasts every year is when we chat with EAU Guideline gurus Derya Tilki and Gianluca Giannarini about the latest updates to the EAU Prostate Cancer Guideline. It is a 250 word document which is updated in March every year and changes are eagerly awaited around the world.…
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Journal club #7 | proPSMA and Penile Fractures(!)
Democracy in action! This month's GU Cast Journal Club papers were chosen by an audience vote at our GU Cast Live Event at EAU in London. Therefore today we focus on first, the landmark proPSMA paper which established the superior accuracy of PSMA PET/CT for staging unfavourable intermediate and...
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ASPIRE-ing to answer the Triplet question! With Rana McKay and Deepak Kilari
The trial they said would never be done! Huge congrats to the Alliance for Clinical Trials in Oncology who have recently opened the ASPIRE trial, a phase III randomised trial of ADT + apalutamide (doublet), vs ADT + apalutamide + docetaxel chemotherapy (triplet) for men with mHSPC. 1200 men will…
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From Studio to Stage: GU Cast Live at EAU in London!
Our biggest live show to date! Taking to the huge eUro 2 auditorium at this month's EAU Annual Meeting in London, Declan and Renu bring you a fast-paced, high-energy session packed with favourite guests, controversial topics, behind-the-scenes stories, and lots of great giveaways, all boosted by...
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PRIMARY 2 is positive! PSMA PET/CT moves to early detection
Big day at the EAU Annual Meeting n London today, as our colleague Dr James Buteau (Nuclear Medicine Physician, Peter MacCallum Cancer Centre, Melbourne), reads out the PRIMARY 2 RCT at the Practice-Changing Plenary in London. Plus a simultaneous publication in Lancet Oncology. Big news for the...
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Histolog digital microscopy | All you need to know!
We bring you highlights from a fantastic two day meeting at the ORSI Academy in Belgium, focussing on the hot topic of intra-operative margin assessment (IOMA), especially during prostate cancer surgery. Following on from the publication of the Neurosafe Proof RCT last year, there has been a…
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Win a trip to the APCCC in Lugano!!!
Yes that's right, our great APCCC giveaway is back! We are sending three lucky winners to Lugano to attend the world's best prostate cancer meeting - the Advanced Prostate Cancer Consensus Conference. Just send us a 60 second video to enter. Closing date Fri 13th June 9pm GMT. Winners will be...
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Journal Club #6 | POUT and SEMS
Welcome to Episode 6 of our monthly GU Cast Journal Club! Two important papers in upper tract urothelial cancer (the POUT trial of adjuvant chemo post nephro-ureterectomy), and metastatic testicular cancer (the SEMS trial of surgery for early metastatic seminoma). We are delighted to welcome back...
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ARPIs, SPARC and Organised Prostate Testing | With Anders Bjartell
It is the eve of the USANZ ASM here in Melbourne (which Renu is Convening!), and some of the 27 International guests are already into town. So we grabbed Anders Bjartell (Lund University/University Hospital Malmo, SWE), for a sit down chat in studio. Anders has been a huge name in prostate cancer...
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Periop EV-Pembro | Do we even need cystectomy anymore?? EV-303 with Christof Vulsteke
Giant bladder cancer paper in NEJM this week with the highly anticipated results of the perioperative EV-Pembro trial (EV-303 / KN-905). Already we can say this is a landmark publicaion in bladder cancer that will change practice and even challenge the role of cystectomy (maybe)! Declan Murphy…
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Neha and Amar on what really matters
Following on from last week's episode on "toxicity", we are delighted today to welcome back two great friends of GU Cast from the world of radiation oncology - ASTRO President Dr Neha Vapiwala (University of Pennsylvania), and European Urology Associate Editor, Dr Amar Kishan (University of...
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GU Toxicity, AI Toxicity & Twitter toxicity!!!
In case you missed it, or you've already abandoned Twitter (memo to self - must do that ourselves!), we witnessed some pretty toxic stuff over there in the past couple of weeks. Vile personal attacks, calls for resignations, accusations of nefarious behaviour etc etc, mostly triggered by an...
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Journal Club #5 | Lamm BCG maintenance and CHAARTED
Happy New Year and welcome to Episode 5 of our monthly GU Cast Journal Club! Today we focus on two classic papers in non-invasive bladder cancer and metastatic prostate cancer. The Lamm RCT of maintenance BCG is a landmark trial for all sorts of reasons, published in J Urol in 2000. And the...
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Focus on China | ESMO prostate cancer highlights
Another of our special Themed Podcasts focussed on prostate cancer in China, supported by our Gold Partner, Bayer. We are joined as ever by our China Editor, Dr Yao Zhu (Fudan University Shanghai Cancer Centre), and also special guest Dr Yige Bao (SCU Xiamen Hospital). Not only do we learn about...
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Journal Club #4 | PRECISION and EB-StaR
Episode 4 of our monthly GU Cast Journal Club and today we focus on two important papers in prostate cancer diagnostics and bladder cancer surgery. The PRECISION NEJM paper 2018 is a landmark publication which defined the role of mpMRI in early detection, and changed practice in many countries.…
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Let's Visit the ORSI Academy! World class robotic surgery training facility
An exclusive behind-the-scenes look at the world-famous ORSI Academy in Belgium! Declan and Renu travelled to this remarkable facility just outside Ghent in Belgium, jammed full of tens of millions of dollars worth of robotic surgery technology from the world's top providers - Intuitive Surgical,...
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Sexual health following prostate cancer treatment | With Chris Nelson
World-renowned sexual health expert, Dr Chris Nelson, Chief of Psychology at Memorial Sloan-Kettering Cancer Centre, joins us in studio to run through the new Movember-supported "Guidelines for Sexual Health Care for Prostate Cancer Patients". A really helpful overview and structure for anyone...
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Is high-risk BCR really mHSPC?? Live webinar replay
We recently hosted another live webinar for our Gold Partners, Mundipharma, this time asking the question, "Is high-risk BCR actually metastatic prostate cancer??". It's a reasonable question! This podcast was anchored from the GU Cast studio in Melbourne by usual hosts, Renu Eapen and Declan...
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SABR and LuPSMA for mHSPC? Let's talk LUNAR
Dr Amar Kishan (Radiation Oncologist, UCLA, USA), made lots of headlines recently when he presented data from the phase II randomised LUNAR trial of SABR +/- LuPSMA in patients with oligometastatic prostate cancer. So we were very happy when he turned up in Melbourne recently and popped into the…
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Let's do some UroTraining! WIth Gonzalo Vitagliano & Maxi Ringa
Fun today as we go to the OR to test drive some high-fidelity radical prostatectomy models and chat with the team behind UroTrainer - world leaders in urologic simulation. Urologists Gonzalo Vitagliano and Maxi Ringa join us from Buenos Aries to tell us all about UroTrainer and why they have…
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In London for #ERUS25 - a festival of robotic surgery!
One of our favourite meetings of the year! The EAU Robotic Urology Section (ERUS) Annual Meeting took place in London recently and was an unashamed exposition of robotic surgery in urology. More than 30 amazing live surgeries, and some fantastic plenary sessions focussing on technical aspects....
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Journal club #3 | ERSPC and NIAGARA
Episode 3 of our monthly GU Cast Journal Club and today we focus on one classic paper in Urology, and one from recent times - the ERSPC randomised trial of screening in prostate cancer, and the NIAGARA trial evaluating peri-operative immunotherapy in muscle-invasive bladder cancer. We are…
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Augerlicious! The ProsTIC-PCF-GU Cast Global Knowledge Exchange Webinar
Another of our deep-in-the-weeds theranostic webinars in conjunction with our friends at ProsTiC, and the Prostate Cancer Foundation. This one focussed on Terbium-161, a very exciting new option in metastatic prostate cancer. Your hosts are Dr Renu Eapen and Professor Michael Hofman, with Dr…
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And in ADDITION....Lu-PSMA improves outcomes in mHSPC | With Scott Tagawa and Michael Hofman
Hot off the press in the Presidential Plenary at #ESMO25, we chat with Dr Scott Tagawa (Weill-Cornell, USA) about the positive data he just presented from the PSMAddition trial. This is an eagerly awaited phase III randmosied trial of patients with mHSPC, to see if the addition of six cycles of...
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Let's talk Common Sense Oncology
Never heard of Common Sense Oncology?? Well if you enjoy this podcast then we think you will might find the Common Sense Oncology (CSO) movement to be very interesting indeed! Declan Murphy caught up recently with Dr Bishal Gyawali, Medical Oncologist at Queen's University, Kingston, Ontario, to...
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In Taipei for #UAA25
The Urological Association of Asia (UAA) Annual Meeting is always a great cultural event with a focus on the local community. And Taipei certainly put on a great show! Lots of fantastic entertainment and great local cuisine, plus of course a great scientific program, with a focus on AI, single…
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Three Radiation Oncologists and a Urologist walk into a podcasting studio...
They started off by introducing themselves as The Three Horsemen of the Apocalypse - what could possibly go wrong!! Declan couldn't resist the opportunity to invite three very eminent radiation oncologists into the studio when they all happened to be in Melbourne, even if he was particularly...
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In Sydney for #ANZUP25
We never need an excuse to visit Sydney, and for sure when one of our favourite meetings of the year is in the Harbourside City then count us in! The Annual Meeting of ANZUP is something we try and get to every year and have really enjoyed bringing you highlights. This year we catch up with some...
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Journal Club #2 | TRANSLATE and Keynote-564
Episode 2 of our monthly GU Cast Journal Club and today we focus on two key papers from recent times - the TRANSLATE trial of transperineal vs transrectal biopsy, and Keynote-564 on the role of adjuvant pembrolizomab following nephrectomy. After great feedback from last month's launch episode, we...
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Cyberknife - who and what is it good for?
We poke around under the hood of a brand new Cyberknife facility here in Melbourne, the first on the East coast of Australia, and find out what it's all about. What is it for, who might benefit, and being surgeons we have to ask, why do they call it a "knife"?! Is it just to make it sound a bit...
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Bye bye gadolinium! PRIME demonstrates bpMRI as good as mpMRI
Big news today with the publication in JAMA of the eagerly anticipated PRIME study, a prospective multicentre trial comparing biparametric (bp) with multiparametric (mp) MRI in men suspected of having prostate cancer. Of course, mpMRI includes contrast enhanced sequences following injection of...
About this show
A urology podcast, focussing on prostate cancer, kidney cancer, bladder cancer, testis and penile cancer. Join Professor Declan Murphy and Dr Renu Eapen from Peter MacCallum Cancer Centre in Melbourne for this regular dive into the world of genitourinary (GU) Oncology and Urology. Regular guests from all over the world, from every walk of life. Find out more gucast.org
Hosted by
Professor Declan Murphy & Dr Renu Eapen