Ep 17: Moonlighting Protein

The International Conference on Biological Inorganic Chemistry (ICBIC) Dr. Harry B. Gray RepArtZymes IPD Summer Program Chemdraw Ketcher SMILES RosettaFold3 (open-source) Making Boltz Structure Predictions in ChimeraX Boltz-2 Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders: https://www.biorxiv.org/content/10.1101/2025.08.14.670059v1 RFdiffusion2 岡本グループの２つ目の人工金属酵素 A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis: https://www.nature.com/articles/s41467-025-61909-5 ちなみに1つ目の人工金属酵素(光駆動型+抗体の修飾) Switching TypeI/TypeII Reactions by Turning a Photoredox Catalyst into a Photo-Driven Artificial Metalloenzyme https://doi.org/10.1021/acscatal.2c05946 2009年ごろの金属イオンを二つ配位させたDe novoデザインタンパク質の論文 from DeGrado Labの一つ An artificial di-iron oxo-protein with phenol oxidase activity https://www.nature.com/articles/nchembio.257 炭酸イオンをトラップできる亜鉛三核の合成触媒 Trinuclear zinc complexes for biologically relevant μ3-oxoanion binding and carbon dioxide fixation: https://www.nature.com/articles/ncomms3375 Dr. Woon Ju Song Accurate computational design of artificial metalloproteins using Metal-Installer https://www.cell.com/chem/fulltext/S2451-9294(25)00234-7