EP 46 - Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosis - P. Milani

In questo studio Bomsztyk e colleghi documentano l’applicazione della spettrometria di massa per la valutazione della risposta ematologica in un’ampia coorte di pazienti affetti da amiloidosi AL, seguiti presso il centro amiloidosi di Londra. L’ottenimento di una negatività alla valutazione in spettrometria di massa è risultato essere associata a un migliore outcome rispetto ad ottenere la sola remissione ematologica completa, secondo gli attuali criteri validati basati su immunofissazione di siero ed urine e misurazione delle catene leggere libere circolanti. Questo studio mostra per la prima volta la possibilità di identificare un sottogruppo di pazienti con sopravvivenza migliore ma studi su più ampie casistiche saranno necessari per confermare tali risultati. Bibliografia Bomsztyk J, et al. Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosis. Blood. 2024 Mar 28;143(13):1259-1268.https://pubmed.ncbi.nlm.nih.gov/38194690/

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EP 46 - Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosis - P. Milani

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