EP 66 GLP-1s, Hormones, and the Metabolic Shift episode artwork

EPISODE · Mar 17, 2026 · 39 MIN

EP 66 GLP-1s, Hormones, and the Metabolic Shift

from UPLEVEL: Real Health, Real Talk with Dr. Jenna Blasi · host Dr. Jenna Blasi

GLP-1 medications are changing the weight-loss conversation, but what happens when you view them as a metabolic tool instead of a shortcut? In this episode of UPLEVEL, Dr. Jenna delves into how GLP-1s can be integrated into a comprehensive strategy for achieving metabolic health, informed choices, and sustainable change. She breaks down what GLP-1s actually do in the body, why their effects go far beyond appetite, and how they can quiet food noise by reducing metabolic stress. She explains who these medications are best suited for, how dosing and pacing can affect side effects, and why muscle preservation, nutrition, and resistance training are important for achieving long-term results. Dr. Jenna also connects the dots between hormones and menopause, unpacking how the midlife metabolic shifts insulin sensitivity, and why some people are exploring microdosing alongside lifestyle changes. Tune in to learn how to use GLP-1 medications effectively to maximise energy, longevity, clarity, and regulation.Key Points From This Episode:Hear the basics of GLP-1 medications and what they actually do.Explore how they affect metabolism beyond influencing appetite.Uncover the benefits of metabolic stability for appetite signals. Learn what metabolic threat load is and how it drives food urgency.Who GLP-1 medications are for and the possible side effects.Unpack the concept of microdosing and why it has become popular.The connection between gut health, foundational habits, and hormones.What someone should consider when thinking of using GLP-1 medications. Understand how menopause shifts metabolism and impacts appetite.How GLP-1s and hormone therapy can act as complementary tools.Links Mentioned in Today’s Episode:Episode 65: Hunger & Cravings Aren’t the Problem – They’re SignalsUPLEVEL Holistic HealthUPLEVEL Holistic Health on InstagramBook Your FREE Discovery Call with Dr. Jenna Blasi

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GLP-1 medications are changing the weight-loss conversation, but what happens when you view them as a metabolic tool instead of a shortcut? In this episode of UPLEVEL, Dr. Jenna delves into how GLP-1s can be integrated into a comprehensive strategy for achieving metabolic health, informed choices, and sustainable change. She breaks down what GLP-1s actually do in the body, why their effects go far beyond appetite, and how they can quiet food noise by reducing metabolic stress. She explains wh...

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EP 66 GLP-1s, Hormones, and the Metabolic Shift

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This episode was published on March 17, 2026.

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