Ep707《林栗伃》2026年最新研究：身體有肥胖記憶

你的脂肪細胞，其實一直在等你鬆懈論文 1（2024 年《自然》期刊，蘇黎世聯邦理工學院 —— 即使在減重後，脂肪細胞仍會透過表觀遺傳學「記住」肥胖狀態）論文 2（2026 年《EMBO Reports》，伯明罕大學 / Claudio Mauro —— CD4 T 細胞透過棕櫚酸驅動的甲基化作用帶有相同的記憶，需要 5 到 10 年才會消退）Hinte, L. C., Castellano-Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., Wolfrum, C., Rydén, M., Mejhert, N., Blüher, M., & von Meyenn, F. (2024). Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature, 636(8042), 457–465. https://doi.org/10.1038/s41586-024-08165-7Niven, J., Kucuk, S., Gope, A., Certo, M., Cassidy, F. C., Arana Echarri, A., Ali, S., Ladoukakis, E., Vidali, S., Macchi, C., Amir, S. S., Bergin, R., Davies, S., Perkin, O. J., Smith, J., Cucchi, D., Heneghan, H., Wijesinghe, S., Jenkins, B. J., … Mauro, C. (2026). DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation. EMBO Reports, 27(11), 3120–3152. https://doi.org/10.1038/s44319-026-00765-w