EPISODE · Feb 12, 2026 · 24 MIN
Episode 108: COMT Gene - The Wired “Warrior” Vs. the Low-Dopamine “Worrier”
from Wholistic Living · host Marla Pietruszko
Why can one person drink coffee at night and sleep fine while another feels anxious and wired for 12 hours? Why do some people thrive on high-dose B vitamins while others spiral into panic and insomnia? Why does estrogen feel overwhelming for some but not others? The answer may lie in one powerful gene: COMT.In this episode of Wholistic Living, we break down the two COMT personality types and how they influence mood, stress response, sleep, hormones, and caffeine tolerance. Slow COMT is often the intense, driven, high-dopamine type. These individuals are focused and sharp but may be prone to anxiety, overthinking, insomnia, estrogen dominance, and caffeine sensitivity. Stress lingers in the system. Hormones feel stronger. B vitamins can overstimulate. Fast COMT is often the lower-dopamine, stimulation-seeking type. These individuals may feel less motivated or more fatigued and may rely on caffeine. They clear stress quickly but also clear dopamine quickly. Too many methyl donors like B9 and B12 can reduce dopamine even further and worsen low mood or lack of drive. In this episode, you will learn:How COMT regulates dopamine, adrenaline, and estrogen detoxWhy slow COMT can contribute to PMS, PMDD, histamine issues, and insomniaWhy fast COMT can affect motivation and moodHow methylated B vitamins influence each variant differentlyWhy caffeine tolerance is genetically influencedHow to structure your diet and lifestyle based on your COMT typeGenetics are not your destiny, but they are your blueprint. If you have ever felt wired and tired, anxious from supplements, hormonally intense, or chronically unmotivated, this episode will help you understand why. Root cause work begins with understanding your terrain.Equip Foods Grass-fed beef protein - Code: MARLAWant to work with me? email me to [email protected]
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Episode 108: COMT Gene - The Wired “Warrior” Vs. the Low-Dopamine “Worrier”
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