Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health episode artwork

EPISODE · May 20, 2026 · 28 MIN

Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health

from Solving the Puzzle with Dr. Datis Kharrazian

In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue.We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You’ll discover why bagfuls of supplements aren’t enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins.Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromesTo become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 Factors affecting mitochondrial function03:55 Optimizing patient bioenergetics basics09:27 Mitochondria and cell evolution12:33 Focus on acquired mitochondrial dysfunctions14:23 Mitochondrial ATP production process20:22 Ketogenic diet and energy pathways21:15 Ketogenic diet for chronic fatigue27:02 Exploring functional medicine resourcesSupport this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

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Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health

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This episode was published on May 20, 2026.

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