PODCAST · health
Solving the Puzzle with Dr. Datis Kharrazian
by Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN
Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases. His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complet
Episodes
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Episode 109: Leaky Gut & LPS: What Every Practitioner Should Know
In this episode, Dr. Liz Lipski covers what drives intestinal permeability, how LPS affects inflammation, autoimmunity, the brain, and the skin, which tests are most useful, and practical healing strategies like glutamine, zinc carnosine, quercetin, demulcents, and bone broth. Enroll now in:...
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Episode 108: Digestive Wellness with Dr. Liz Lipski
Dr. Liz Lipski discusses how to choose the right elimination diet for each patient, why gut healing should be temporary, how resilient the microbiome really is, GLP-1s and Akkermansia, and which gut tests are actually useful. Enroll now in: Insights into Digestive Wellness, with Liz Lipski, PhD,...
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Episode 107: Digestive Enzymes and the Overlooked Signs of Pancreatic Insufficiency
Liz Lipski breaks down the three main types of digestive enzymes, how to test for pancreatic exocrine insufficiency using fecal elastase, and how to choose the right product for each patient. She walks through prescription options, full spectrum supplements, lipase-loaded formulas, and food-based...
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Episode 106: Ferritin, Iron Deficiency & Iron Overload
Ferritin is one of the most misunderstood markers on a blood test. A low-normal result doesn’t automatically mean iron deficiency, and an elevated result doesn’t necessarily mean iron overload. In this episode, Dr. Datis Kharrazian explains how ferritin reflects iron storage and inflammation, why...
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Episode 105: The Future of AI in Clinical Practice
Sunjya Schweig looks at where AI in clinical practice is headed over the next one to three years, from AI native EMRs and ambient scribing to fully integrated clinical copilots that surface real time insights and automate routine tasks. He outlines what practitioners who build fluency now will…
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Episode 107: AI in a functional medicine - with Dr. Sunjya Schweig
Dr. Sunjya Schweig explains how AI is changing day-to-day clinical work in functional medicine. He walks through his clinic's HIPAA-compliant Claude setup and the workflow he uses to compare answers across multiple LLMs. He also makes the case for practitioners to move beyond simply querying...
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Episode 104: The Next Frontier of AI in Functional Medicine
In this podcast Sunjya Schweig breaks down what AI agents actually are, how they differ from standard chat tools, and what they can realistically do in a clinical setting right now. He walks through the main platforms, real world use cases, and the safety protocols every practitioner needs to...
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Episode 103: Seed Oils Explained: Separating Oxidized Cooking Oils from Essential Fatty Acids
Seed oils have become a nutritional villain, but the real issue is more specific: oxidation. In this episode, Dr. Datis Kharrazian explains why heat and light can damage unstable oils, while cold-pressed options such as flaxseed, evening primrose, and black currant oil can provide essential fatty...
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Episode 102: Using AI to Build Practical Functional Medicine Care Plans
AI can process enormous amounts of clinical information in seconds, but it has never seen a patient, built a clinical relationship, or developed clinical judgment through experience. This episode examines how AI can support treatment planning without replacing the clinician’s reasoning. Enroll…
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Episode 101: Navigating Functional Medicine in a Small Town with Dr. Edling
In today’s Practitioner Spotlight, we speak with Dr. Edling, a seasoned chiropractor and functional medicine practitioner from the small town of Osceola, Wisconsin. With over 20 years of experience integrating functional medicine into a rural practice, he shares the unique challenges and rewards…
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Episode 100: Understanding GLP-1 Risks: Navigating the Complexities of Weight Loss Medications
GLP-1 medications, widely celebrated for their ability to break the cycle of metabolic syndrome, obesity, and diabetes, are not without risks and lesser-known downsides. Dr. Kharrazian explains the long-term effects of a constant catabolic state, including its impact on muscle mass, digestion,...
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Episode 99: Rewiring Unhealthy Behaviors in Functional Medicine
Today, David Musnick dives into the science and art of assessing and changing health habits. From identifying the unconscious routines that sabotage our wellness to learning practical strategies for breaking unhealthy patterns and stacking new positive behaviors, this episode guides practitioners...
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Episode 98: Rewiring Your Mind: How Cognitive Distortions and Labeling Block Healing
In today’s episode, David Musnick dives into the concept of cognitive distortions, those faulty ways of thinking that can hold us back from healing and create barriers in our health journeys. Drawing on the influential work of Dr. David Burns, Dr. Musnick breaks down the most common cognitive...
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Episode 97: Key Steps to Help Patients Navigate Complex Functional Medicine Protocols
In this episode, we establish effective priorities and clear communication with patients to reduce overwhelm, improve compliance, and achieve better outcomes, especially when managing chronic health, gut, brain, or autoimmune conditions. We’ll explore strategies for setting mutually agreed...
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Episode 96: Diet, Sleep & Circadian Rhythm for Fatigue Syndromes
In this episode we dive into the metabolic and lifestyle foundations that drive chronic fatigue, ME/CFS, and energy dysfunction. Blood sugar stabilization is covered in depth, from managing hypoglycemia and insulin resistance to the role of ketogenic nutrition in difficult cases that have not...
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Episode 95: The Truth About Hormone Replacement Therapy for Cardiovascular and Cognitive Health
In this episode, Randy Vawdrey dives into the world of hormone optimization, challenging decades of conventional wisdom that has stigmatized hormone therapy, especially for women. You'll hear an evidence-based exploration into the role hormones like DHEA, estrogen, progesterone, and testosterone...
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Episode 94: The Truth About Cholesterol, CAC Scores, and Heart Attack Risk
In today’s episode, Randy Vawdrey dives into cardiovascular prevention with a special focus on coronary artery calcium (CAC) testing. He guides us through why traditional cardiovascular risk factors like LDL cholesterol, HDL, and BMI may not be as predictive of heart attack risk as once thought,...
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Episode 93: Optimizing Omega 3 Levels for Brain and Heart Health
Today, we’re diving into the world of Omega 3 fatty acids with Randy Vawdrey, NP-C. He unpacks why they are so critical for brain and cardiovascular health, how dietary patterns and supplement choices can make or break your Omega 3 levels, and what the latest research tells us about optimal…
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Episode 92: Understanding Chronic Pain and Fatigue
Today, we’re diving into the enigma of chronic pain and fatigue. Dr. Kharrazian unpacks the science and physiology behind pain, revealing that it’s not simply a sensory experience but an intricate interaction between our nerves, brain, and even our emotions. From explanations of hyperalgesia and...
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Episode 91: Managing Musculoskeletal Symptoms in Menopause
In this episode, Leslie Fuller, ND focused on the often-overlooked musculoskeletal symptoms experienced by women during perimenopause and menopause. She discusses strategies for effective management, including nutrition, resistance training, hormone assessment, and addressing both structural and...
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Episode 90: GSM Essentials for 2025: Top Treatment Updates, Safety Guidance, and Patient Impact
In this episode, Jillian Moehle focused on the latest evidence-based strategies for recognizing and treating Genitourinary Syndrome of Menopause (GSM). She explored newly updated guidelines from the American Urological Association, emphasizing the importance of proactive screening, a…
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Episode 89: Why Millions of Women Were Failed by the Women’s Health Initiative Study
In this episode, we’re diving into the complex and often misunderstood topic of menopause and perimenopause. Despite affecting every woman who lives into late life, menopause has long been underfunded, understudied, and minimized both culturally and medically. Today, we’ll explore why clinical…
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Episode 88: Hormone Therapy, Breast Cancer, and Menopause
In today's episode, Dr. Mark Holthouse dives into the fears surrounding breast cancer and hormone replacement therapy, separating myth from evidence with a critical look at the real data. Our expert speaker unpacks the latest clinical trials and position statements, clarifying the nuanced...
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Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health
In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have...
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Episode 86: Oral and Injectable Peptides for Recovery
In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, Lorazatide, TB4, and PeptiStrong, sharing case...
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Episode 85: Transforming Autism Care with Nutrigenetics and Methylation Pathways
In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient support can unlock profound change. We’ll explore...
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Episode 84: Exploring Oxidative Stress, GST Genes, and Hormonal Detox Strategies
In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case...
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Episode 83: The Functional Anatomy of Pain
In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral...
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Episode 82: Micronutrient Deficiency Signs
Today, we're diving into the often overlooked signs and symptoms of micronutrient deficiencies, from vitamins A, D, and K to magnesium, zinc, and beyond. You'll discover how subtle clues like gritty eyes, dream recall, muscle cramps, and even pink tongues can signal deeper nutritional gaps...
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Episode 81: How Skin Reveals Deeper Health Issues and Nutritional Imbalances
In this episode, we’re diving into the world of skin health, from what radiant, healthy skin should look like to the many signals our skin can send about underlying health issues. We'll explore common skin manifestations, nutritional deficiencies, and practical strategies to support skin, from...
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Episode 80: Dr. Darla Booth DC, AFMC, Managing Autoimmune Patients Successfully
In this Practitioner Spotlight episode, we sit down with Dr. Darla Booth, a seasoned chiropractor and functional medicine practitioner based in Los Gatos, California. Over the past 20 years, Dr. Booth has transitioned her practice to focus on complex functional medicine cases, with a special...
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Episode 79: Nutrition Focused Physical Assessment with Dr. Liz Lipski
In this episode, Dr. Liz Lipski, a leader in clinical nutrition and author of Digestive Wellness dives into the foundational practice of nutrition-focused physical assessment. Dr. Lipski explains how simple observations like cracks in a friend’s tongue over dinner or dark circles under a child’s...
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Episode 78: How Mitochondrial Dysfunction Drives Fatigue, Depression, and Chronic Pain Syndromes
In today’s episode, we’re diving into the impact of mitochondria on chronic conditions like fatigue, pain, and depression. You’ll hear why optimizing basic factors like sleep, movement, and stable blood sugar isn’t just “wellness” advice, but can actually be game changers for patients struggling...
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Episode 77: The Root Causes of Chronic Fatigue and Pain Syndromes
In this episode, Dr. Kharrazian dives into one of the most challenging and important topics facing both patients and practitioners: chronic fatigue and pain syndromes. If you've ever wondered why fatigue and pain are such stubborn and complex complaints, or why so many patients feel stuck despite...
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Episode 76: Practical Functional Medicine
Dr. Dave Rakel introduces the ECHO model for medical decision making, a practical framework that evaluates four key factors: Efficacy (evidence of benefit), Cost, Harm (evidence of harm), and Opinion (patient preferences and bias). He emphasizes that treatment decisions should balance not only…
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Episode 75: Dr. Dave Rakel on the Placebo Effect
In this lecture, Dr. Dave Rakel explores the placebo effect—"the ability to stimulate self-healing without deception"—and reveals how perception, connection, and empathy are among the most powerful healing mechanisms available to practitioners. Dr. Rakel unpacks the neuroscience of perception,...
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Episode 74: Practitioner Spotlight: Dr. Dave Boynton on Why Hypoglycemia Destroys Healing, Neurological Exams Save Lives & Cookie-Cutter Protocols Don't Work
In this Practitioner Spotlight, Dr. Dave Boyton—a Cincinnati-based functional medicine specialist—shares how he transformed his practice by integrating neurological assessment with functional medicine. After his wife was misdiagnosed with multiple autoimmune conditions, Dr. Boynton dove deep into...
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Episode 73: Navigating Breast Implant Illness
In this episode, our guest speaker, certified physician assistant Danielle Valoras explores breast implant illness (BII)—a clinical reality that remains widely misunderstood despite affecting millions of women. She unpacks why BII lacks an official diagnosis code, yet presents with a consistent...
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Episode 72: How the Lymphatic System Impacts Women With Breast Implants
In this episode, our guest speaker, certified physician assistant Danielle Valoras explores the essential role of the lymphatic system in women with breast implants. She explains how the lymphatic system serves as the body's drainage and immune defense network, and how disruptions in lymph flow,...
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Episode 71: The Hidden Risks of Breast Implants
In this episode, certified physician assistant Danielle Valoras shares her expertise cultivated from over two decades in medicine—and a decade devoted to functional medicine—by diving into an issue affecting millions: breast implants and their true impact on women’s health. Drawing from both...
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Episode 70: Nutrient-Dense Eating for Fatty Liver
In this episode, Dr. Yousef Elyaman breaks down the essential nutritional strategies for reversing fatty liver disease—from macronutrient optimization to the evidence-based power of the Mediterranean diet—making complex dietary interventions immediately actionable for practitioners and patients.…
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Episode 69: Ketogenic Diets and Fasting for Liver Health with Dr. Yousef Elyaman
In this episode, Dr. Yousef Elyaman breaks down the essential mathematics of metabolism—from calculating basal metabolic rate to understanding the 3,500-calorie rule for weight loss—making complex concepts immediately actionable for practitioners and patients. We explore the critical distinction...
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Episode 68: Understanding the Root Causes of Fatty Liver Disease in Functional Medicine
In this episode, Dr. Yousef Elyaman, a leading functional medicine doctor, takes us into the pathogenesis of fatty liver disease, sharing his expertise on the underlying imbalances and physiological mechanisms that contribute to this complex condition. We explore how functional medicine looks...
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Episode 67: Hallmarks of Aging and Disease
In this episode, Dr. Datis Kharrazian explores longevity medicine and the hallmarks of aging and disease. How do early signs of loss of resilience—like cognitive decline or changes in physical appearance—offer clues about our biological age? What can cutting-edge studies, such as the Dunedin...
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Episode 66: Longevity and Wellness Optimization
In this episode, Dr. Kharrazian covers the physiological mechanisms that drive aging and how you can take proactive steps to slow disease progression and extend your healthspan. Learn the foundational concepts of geroscience, the difference between anti-aging appearance medicine and true…
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Episode 65: Why You're Aging Faster Than You Should
In this episode, Datis Kharrazian bridges complex science with practical strategies you can use right away, focusing on the fascinating concept of biological age versus chronological age. You’ll learn why some people seem to age slower or faster than their years might suggest, and discover how...
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Episode 64: The Impact of Lifestyle and Environmental Factors on Depression and Mood Disorders
In this episode, we dive into the environmental and lifestyle factors that impact mood disorders like depression and anxiety. You'll learn how screen time, diet, sleep, and physical activity can set the stage for mental health—and why toxic exposures like pesticides, heavy metals, air pollution,...
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Episode 63: How Blood Sugar Imbalances and Stress Disrupt Brain Chemistry and Mood Disorders
In today’s episode, Dr. Datis Kharrazian takes a dive into the intricate relationship between blood sugar stability—what he calls dysglycemia—and mood disorders. You'll learn how rollercoaster blood sugar levels can disrupt neurochemistry, impact hormone balance, and even alter your brain’s…
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Episode 62: Mood Disorders Explained: Placebo, Polypharmacy, and the Future of Treatment
In this episode, Dr. Kharrazian dives into the complex world of mood disorders, shining a light on why conditions like depression and anxiety have become such significant global health challenges. He questions the mainstream approach to treating mood disorders, revealing the limitations and…
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Episode 61: Transformative Power of Laser Therapy for Chronic Illness
In this episode, Dr. Kirk Gair dives into the clinical power of laser therapy—bridging the science behind this technology with its practical applications for chronic health issues, brain function, autoimmune conditions, and more. You'll hear real case stories, from a doctor who saw dramatic...
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ABOUT THIS SHOW
Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases.
Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.
His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life.
Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complet
HOSTED BY
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN
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Frequently Asked Questions
How many episodes does Solving the Puzzle with Dr. Datis Kharrazian have?
Solving the Puzzle with Dr. Datis Kharrazian currently has 109 episodes available on PodParley. New episodes are automatically indexed when they're published to the podcast feed.
What is Solving the Puzzle with Dr. Datis Kharrazian about?
Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in...
How often does Solving the Puzzle with Dr. Datis Kharrazian release new episodes?
Solving the Puzzle with Dr. Datis Kharrazian publishes regularly with 109 episodes available. Check the episode list for the typical release schedule.
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Who hosts Solving the Puzzle with Dr. Datis Kharrazian?
Solving the Puzzle with Dr. Datis Kharrazian is created and hosted by Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN.
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