Episodio – 6-mercaptopurina en leucemia linfoblástica aguda: metabolismo y toxicidad | USMLE Step 1

from USMLE DREAMERS · host USMLE DREAMERS

Paciente pediátrico con leucemia linfoblástica aguda en tratamiento de mantenimiento con 6-mercaptopurina. En este episodio revisamos el metabolismo de la 6-MP, su activación por HGPRT hacia metabolitos citotóxicos y las dos vías clave de inactivación: xantina oxidasa y tiopurina metiltransferasa. Analizamos la relevancia clínica de la interacción con alopurinol y la deficiencia genética de TPMT, causas frecuentes de toxicidad grave. Un episodio esencial de farmacología oncológica e inmunosupresión.#USMLEDreamers #USMLE #Step1 #Farmacologia #Oncologia #Hematologia #Leucemia #6MP #Azatioprina #TPMT #XantinaOxidasa

Episode metadata supplied by the publisher feed · Published Jan 7, 2026

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Episodio – 6-mercaptopurina en leucemia linfoblástica aguda: metabolismo y toxicidad | USMLE Step 1

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