Episodio – Enfermedad de Paget del hueso: fases, osteoclastos gigantes y eje RANK–RANKL | USMLE Step 1 episode artwork

EPISODE · Jan 2, 2026 · 6 MIN

Episodio – Enfermedad de Paget del hueso: fases, osteoclastos gigantes y eje RANK–RANKL | USMLE Step 1

from USMLE DREAMERS · host USMLE DREAMERS

Varón adulto mayor con dolor óseo progresivo, deformidad tibial y pérdida auditiva presenta hallazgos histológicos de osteoclastos gigantes multinucleados. En este episodio analizamos de forma integrada la enfermedad de Paget del hueso, su evolución en fases (osteolítica, mixta y osteoesclerótica), el origen hematopoyético del osteoclasto y la vía molecular RANK–RANKL como eje central del recambio óseo patológico.#USMLEDreamers #USMLEStep1 #MetabolismoÓseo #PagetDisease #Osteoclasts #RANKL #BoneRemodeling

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Episodio – Enfermedad de Paget del hueso: fases, osteoclastos gigantes y eje RANK–RANKL | USMLE Step 1

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