Episodio – Leptina y obesidad: resistencia central y mutación del receptor | USMLE Step 1

from USMLE DREAMERS · host USMLE DREAMERS

En este episodio analizamos en profundidad el papel fisiológico de la leptina en la regulación del apetito y el peso corporal, y cómo las mutaciones en su receptor generan obesidad severa por resistencia central a la señalización. A través de un modelo experimental clásico con ratones knockout del receptor de leptina, revisamos la relación entre BMI y niveles séricos de leptina, diferenciando claramente entre defectos de producción hormonal y defectos de señalización. Un tema clave para comprender obesidad, neuroendocrinología y fisiopatología integrativa.#USMLE #USMLEDreamers #Endocrinología #Leptina #Obesidad #Fisiología #Step1 #Neuroendocrino #Metabolismo #Hipotálamo

Episode metadata supplied by the publisher feed · Published Jan 8, 2026

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Episodio – Leptina y obesidad: resistencia central y mutación del receptor | USMLE Step 1

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