Episodio – Milrinona en IC sistólica: inhibición de PDE-3, inotropía positiva y vasodilatación | USMLE Step 1

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Paciente con miocardiopatía no isquémica y descompensación de insuficiencia cardíaca con signos de congestión (disnea, ortopnea, PVC elevada, estertores bibasales, S3 y edema). Se inicia milrinona. En este episodio explicamos, paso a paso, cómo la inhibición de la fosfodiesterasa-3 aumenta el cAMP en cardiomiocitos y músculo liso vascular, produciendo inotropía positiva y vasodilatación. Integramos la fisiología del calcio, el efecto sobre precarga y poscarga, y por qué la respuesta más probable es vasodilatación, aun con riesgo de hipotensión.#USMLEDreamers #USMLE #Step1 #Cardiologia #Farmacologia #InsuficienciaCardiaca #Milrinona #PDE3 #cAMP #Inotropia #Vasodilatacion

Episode metadata supplied by the publisher feed · Published Jan 7, 2026

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Episodio – Milrinona en IC sistólica: inhibición de PDE-3, inotropía positiva y vasodilatación | USMLE Step 1

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