Expert Perspectives on the 2026 Acute PE Guideline | JACC Journal Club

In this JACC Journal Club session, host and JACC Education Editor Dr. Vivek Kulkarni sits down with the chairs of the 2026 Multi-Society Guideline for the Evaluation and Management of Acute Pulmonary Embolism, Dr. Mark Creager, Dr. Geoffrey Barnes and Dr. Jay Giri, to break down what's new, what changed, and what it means for clinical practice. Topics covered include: • Behind the scenes: how a major guideline gets written • PE risk stratification and the new classification framework • PERT programs — who needs one and how to build one • Advanced therapies: catheter-directed treatment, thrombectomy, and systemic thrombolysis • Upcoming mega-trials to watch (PEERLESS, HI-PEITHO, Python, and more) • How and when guideline updates can be expected Access the full guideline and JACC focus issue via the links below: Guideline: https://www.jacc.org/doi/10.1016/j.jacc.2025.11.005 Focus Issue: https://www.jacc.org/toc/jacc/87/13