JACC Journal Club

In this JACC Journal Club session, host and JACC Education Editor Dr. Vivek Kulkarni sits down with the chairs of the 2026 Multi-Society Guideline for the Evaluation and Management of Acute Pulmonary Embolism, Dr. Mark Creager, Dr. Geoffrey Barnes and Dr. Jay Giri, to break down what's new, what changed, and what it means for clinical practice. Topics covered include: • Behind the scenes: how a major guideline gets written • PE risk stratification and the new classification framework • PERT programs — who needs one and how to build one • Advanced therapies: catheter-directed treatment, thrombectomy, and systemic thrombolysis • Upcoming mega-trials to watch (PEERLESS, HI-PEITHO, Python, and more) • How and when guideline updates can be expected Access the full guideline and JACC focus issue via the links below: Guideline: https://www.jacc.org/doi/10.1016/j.jacc.2025.11.005 Focus Issue: https://www.jacc.org/toc/jacc/87/13

In this JACC Journal Club session, we explore the 2025 ACC/AHA Guideline for the Management of Acute Coronary Syndromes (ACS). This session features Dr. Sunil Rao, Chair of the ACS Guideline Writing Committee, who will walk participants through key updates, the evidence behind new recommendations, and practical applications for clinical care.

In this JACC Journal Club session, we explore groundbreaking research on novel therapies for transthyretin (TTR) amyloidosis featuring Drs. Matthew Maurer and Michelle Kittleson. Learn how acoramidis and vutrisiran impact survival, how biomarkers like serum TTR/prealbumin guide therapy, and why early diagnosis is critical. This expert-led discussion offers clinical insights on managing ATTR-CM, optimizing treatment strategies, and improving patient access to care.

In this session of JACC Journal Club, we explore cutting-edge research on tricuspid transcatheter interventions, focusing on the TRISCEND II and TRILUMINATE trials. JACC Education Editor Vivek Kulkarni, MD, MHS, EdM, FACC and his co-lead, Megan Burke, MD, along with Suzanne Arnold, MD, JACC: Case Reports Editor-in-Chief Gilbert H. L. Tang, MD, MSc, MBA, FACC, Paul Fiorilli, MD, FACC, and Sajjad Sabir, MD discuss patient selection, procedural techniques, and key clinical findings, including the impact of quality of life improvements and the evolving role of tricuspid valve therapies. We also address methodological controversies, right heart function assessment, and the challenges of treating atrial functional TR. Additionally, we examine the long-term implications of transcatheter interventions and the potential for future clinical advancements in tricuspid regurgitation treatment. Join us as we unpack the latest evidence, clinical insights, and future directions in this rapidly advancing field!

Explore the key findings and clinical implications of the SUMMIT CMR Substudy in this engaging webinar. Hear from study authors Christopher M. Kramer, MD, FACC, and Milton Packer, MD, FACC, alongside JACC Education Editor Vivek Kulkarni, MD, MHS, EdM, FACC, and contributors Natalie Stokes, MD, MPhil, MSc, and Harish Jarrett, MD, FACC.