Fatty Liver, Fiercer Metastases, Future Targets 🧬

🧬 New Nature study: fatty liver may do more than coexist with colorectal cancer liver metastases — it may shape their biology. Steatotic livers were linked to more aggressive "replacement" metastases, driven by fatty acid oxidation, MYC stabilization, proline synthesis, and collagen remodeling.  The practical pearl: liver-fat content may become a biomarker for prognosis and trial selection, especially for MYC-targeted therapy. Metabolism is not background noise — it may be the soil that scripts metastatic fate. 🎯