Glycans, Glucosamine, and Alzheimer's: A Warning ?⚠️🧬

🧠🍬 Beyond plaques and tangles, could Alzheimer's disease also be driven by excess protein "sugar-coating"?   A new Nature Metabolism study identifies brain hyperglycosylation as a conserved metabolic feature of AD, driven by increased N-glycan biosynthesis. Lowering glycosylation improved memory in mouse models, while glucosamine worsened outcomes and showed concerning real-world signals in dementia cohorts.   A sweet pathway with bitter implications. ⚠️🧬   #AlzheimersDisease #Glycomics #Neurodegeneration #MedicalPodcasts